TRAINING AND RESEARCH ON SEVERE MALARIAL ANEMIA

描述（由申请人提供）：本提案是我们最初资助的福格蒂国际中心申请（D43 TW05884）题为“严重疟疾性贫血的培训和研究”的竞争延续，以及我们用补充资金建立的“扩大严重疟疾性贫血的研究，包括艾滋病毒/疟疾合并感染领域的培训和研究”的额外项目。在续期申请中，我们建议为两名肯尼亚博士后、两名博士候选人和一名本科生提供继续培训，这些本科生曾在2002年成立的匹兹堡大学国际疟疾培训与研究项目（IMTRP）中接受过培训。此外，我们将招聘和培训一名肯尼亚博士候选人，作为竞争延续的一部分。该项目还将包含一项再入境资助，以便肯尼亚科学家能够在肯尼亚建立他们独立的研究事业。为了实现我们的培训目标，我们将继续与肯尼亚内罗毕的肯雅塔大学和肯尼亚基苏木的肯尼亚医学研究所（KEMRI）合作。由于该机构位于我们在肯尼亚西部的研究培训设施附近，并提供与我们的培训目标平行的新建立的学术课程，因此将与马塞诺大学（肯尼亚西部）形成额外的合作关系。全球传染病培训将以儿童严重疟疾性贫血和HIV- 1为重点，受训者将接受遗传学、分子免疫学、生物信息学和生物统计学方面的深入指导。研究培训将在我们在肯尼亚西部最先进的设施中进行，肯尼亚西部是恶性疟原虫全面流行的地区，也是肯尼亚儿童艾滋病毒-1感染率最高的地区。此外，我们将通过年度研讨会为25-30名肯尼亚博士后、博士和医科学生以及硕士级别的学员提供短期强化培训。这项短期培训将在肯尼亚西部的KEMRI研究机构进行，并将由来自美国和肯尼亚的科学专家授课。将提供遗传学、分子免疫学、血液学、流行病学、生物统计学、生物信息学、生物伦理学以及小儿疟疾和艾滋病毒-1临床管理方面的培训。我们在竞争延续中设计的总体培训模式将确保匹兹堡大学IMRTP的所有受训人员获得必要的技术和知识专长，以便为控制和预防儿童疟疾和艾滋病毒-1进行独立研究。我们非常成功的培训方案的继续进行还将提供必要的技术转让和能力建设，以便建立一支关键的肯尼亚科学家队伍，以长期解决与疟疾和艾滋病毒-1有关的具有挑战性的公共卫生问题。

DESCRIPTION (provided by applicant): This proposal is the competing continuation of our originally funded Fogarty International Center application (D43 TW05884) entitled, Training and Research in Severe Malarial Anemia, and the additional program we established with supplemental funding entitled, Expanding Research on Severe Malarial Anemia to Include Training and Research in the Areas of HIV/Malaria Co-Infections. In the renewal application, we propose to provide continued training for two Kenyan postdoctoral fellows, two doctoral candidates, and an undergraduate student who received training in the previously funded University of Pittsburgh International Malaria Training and Research Program (IMTRP) established in 2002. In addition, we will recruit and train an additional Kenyan doctoral candidate as part of the competing continuation. The program will also contain a re-entry grant so that Kenyan scientists can establish their independent research careers in Kenya. To accomplish our training goals, we will continue our collaboration with Kenyatta University in Nairobi, Kenya, and the Kenya Medical Research Institute (KEMRI), Kisumu, Kenya. An additional collaborative relationship will be formed with Maseno University (western Kenya), since this institution is located near our research training facilities in western Kenya and offers newly established academic programs that parallel our training goals. Global infectious disease training will focus on pediatric severe malarial anemia and HIV- 1, and trainees will receive in-depth instruction in genetics, molecular immunology, bioinformatics, and biostatistics. The research training will take place at our state-of-the-art facilities in western Kenya, a region with holoendemic Plasmodium falciparum transmission and the highest rates of pediatric HIV-1 in Kenya. In addition, we will provide short-term intensive training to 25-30 Kenyan postdoctoral fellows, doctoral and medical students, and masters' level trainees through annual workshops. The short-term training will take place at the KEMRI research facility in western Kenya and will be taught by scientific experts from the US and Kenya. Training will be provided in genetics, molecular immunology, hematology, epidemiology, biostatistics, bioinformatics, bioethics, and clinical management of pediatric malaria and HIV-1. The overall training paradigm we have designed in the competing continuation will ensure that all trainees in the University of Pittsburgh IMRTP receive the required technical and intellectual expertise to conduct independent research for the control and prevention of pediatric malaria and HIV-1. Continuation of our highly successful training program will also provide the essential technology transfer and capacity-building required for establishing a critical mass of Kenyan scientists to address the challenging public health problems associated with malaria and HIV-1 on a long-term basis.