2012 Aging, Biology of GRC & GRS

描述(由申请者提供)：2012年戈登衰老生物学研究会议(GRC)将是自1962年该系列成立以来的第28次。这个系列很重要，因为衰老的基础生物学研究在大型社会会议上的代表性很低，这些会议传统上主要强调老年学问题及其医学、社会和心理分支。因此，基础科学研究人员寻求将老龄化生物学全球研究中心作为讨论该领域最新进展、介绍新的实验模型、范式的挑战、联网和发起合作项目的理想论坛。然而，在这次研讨会的历史上，该领域比以往任何时候都更准备开始将翻译研究整合到模式生物衰老的基础生物学中。因此，2012年老龄化生物学全球研究报告将聚焦于“衰老的遗传、表观遗传、炎症和代谢起源”。该计划专注于近年来衰老生物学的四个主要进展，这些进展以前从未在这次或其他类似会议上集中在一起：表观遗传机制，如由microRNA和基因组CpG岛甲基化调节；子宫内发育；异常长寿的人的大而公正的基因组筛选；以及容易虚弱、慢性病和健康寿命缩短的细胞功能障碍和衰老。所有这些都极大地扩展了老龄化研究的视野，并暗示了对有可能提高健康寿命的干预措施的追求。虽然我们关于衰老生物学的大部分知识都来自于使用模型生物的研究，但最近人类已经成为实验的对象，这些实验测试这些机制被保存得有多好，以及它们如何影响与年龄相关的疾病。未来的目标必须是在人类身上成功验证从模型系统收集的信息，并使用模型系统询问人类基因组。因此，这些不同领域的研究人员之间的相互反馈是2012年衰老生物学GRC的主要目标之一。为了实现这一目标，2012年老龄生物学全球研究委员会将：1)促进对关键问题的公开讨论，特别强调可能对人类老龄化具有重要翻译潜力的新机制；2)为讨论老龄生物学研究的最新进展提供一个论坛；3)促进思想交流和研究结果的沟通，以确定该领域的未来目标；4)促进联网，发起国际合作努力，以及财团；以及，5)促进初级研究人员融入既定的老龄研究人员社区。为实现这最后一个目标，将举办一次戈登-凯南研究研讨会，致力于培训学员的智力和心理准备，以便充分参与随后的全球资源中心。 公共卫生相关性：项目叙述2012年戈登老龄生物学研究会议(GRC)将是自1962年该系列开始以来的第28次。这个系列很重要，因为衰老的基础生物学研究在大型社会会议上的代表性很低，这些会议传统上主要强调老年学问题及其医学、社会和心理分支。然而，在这次研讨会的历史上，该领域比以往任何时候都更准备开始将翻译研究整合到模式生物衰老的基础生物学中。因此，2012年老龄化生物学全球研究报告将聚焦于“衰老的遗传、表观遗传、炎症和代谢起源”。虽然我们关于衰老生物学的大部分知识都来自于使用模型生物的研究，但最近人类已经成为实验的对象，这些实验测试这些机制被保存得有多好，以及它们如何影响与年龄相关的疾病。未来的目标之一必须是在人类身上成功验证从模型系统收集的信息，并使用模型系统询问人类基因组。因此，这些不同领域的研究人员之间的相互反馈是2012年衰老生物学GRC的主要目标之一。第二个目标是为下一代基础科学家在老龄化研究领域发挥领导作用做好准备。为了帮助我们的初级同事充分利用GRC，我们将在GRC的周末举办戈登研究研讨会，旨在克服智力和心理障碍，全面参与随后的会议。

DESCRIPTION (provided by applicant): The 2012 Gordon Research Conference (GRC) on Biology of Aging will be the twenty-eighth of its kind since inception of the series in 1962. This series is important because research in basic biology of aging has been poorly represented in the large society meetings that have traditionally maintained a major emphasis on gerontological issues and their medical, social and psychological ramifications. Consequently, basic science investigators have sought the GRC on Biology of Aging as the ideal forum for discussion of recent advances in the field, presentation of new experimental models, challenge of paradigms, networking and initiation of collaborative projects. More than at any previous time in the history of this symposium, however, the field is ready to begin to integrate translational research into the basic biology of aging in model organisms. Hence, the 2012 GRC on the Biology of Aging will focus on the "Genetic, epigenetic, inflammatory, and metabolic origins of aging." The program focuses on four major advances in the biology of aging in recent years, which have not been brought together previously in this or other similar conferences: epigenetic mechanisms, such as regulation by microRNAs and by genomic CpG island methylation; intra-uterine development; large, unbiased genomic screens in people with exceptional longevity; and, cellular dysfunction and senescence that predisposes to frailty, chronic diseases, and diminished healthspan. All of these greatly expand the horizons of aging research and suggest the pursuit of interventions that have the potential to enhance healthspan. While much of our knowledge about the biology of aging has derived from studies using model organisms, recently humans have become the subjects of experiments that test how well these mechanisms are conserved and how they impact age-related diseases. The goal for the future has to be both the successful validation in humans of information gleaned from model systems and the interrogation of the human genome using model systems. Therefore, reciprocal feedback between investigators in these diverse fields is one of the main objectives of the 2012 Biology of Aging GRC. To accomplish this objective, the 2012 GRC on the Biology of Aging will: 1) promote open discussion of critical questions with particular emphasis on novel mechanisms that could have important translational potential for human aging; 2) provide a forum for the discussion of state-of- the art advances in research in biology of aging; 3) facilitate exchange of ideas and communication of findings that could shape the future goals of the field; 4) promote networking, initiation of international cooperative efforts, and consortiums; and, 5) promote the integration of junior investigators into the established community of aging researchers. This last objective will be met by inclusion of a Gordon-Kenan Research Seminar dedicated to the intellectual and psychological preparation of trainees for full participation in the GRC to follow. PUBLIC HEALTH RELEVANCE: Project Narrative The 2012 Gordon Research Conference (GRC) on Biology of Aging will be the twenty-eighth of its kind since inception of the series in 1962. This series is important because research in basic biology of aging has been poorly represented in the large society meetings that have traditionally maintained a major emphasis on gerontological issues and their medical, social and psychological ramifications. More than at any previous time in the history of this symposium, however, the field is ready to begin to integrate translational research into the basic biology of aging in model organisms. Hence, the 2012 GRC on the Biology of Aging will focus on the "Genetic, epigenetic, inflammatory, and metabolic origins of aging." While much of our knowledge about the biology of aging has derived from studies using model organisms, recently humans have become the subjects of experiments that test how well these mechanisms are conserved and how they impact age-related diseases. One of the goal for the future has to be both the successful validation in humans of information gleaned from model systems and the interrogation of the human genome using model systems. Therefore, reciprocal feedback between investigators in these diverse fields is one of the main objectives of the 2012 Biology of Aging GRC. A second goal is to prepare the next generation of basic scientists for leading roles in the field of aging research. In order to assist our junior colleagues in taking full advantage of the GRC, we will offer a Gordon Research Seminar on the weekend of the GRC, which is intended to overcome intellectual and psychological roadblocks to full participation in the ensuing meeting.