Einstein's Nathan Shock Center of Excellence in Basic Biology of Aging

描述(由申请者提供)：这是变革性的爱因斯坦·内森冲击中心(E-NSC)的第一次竞争性续签。在第一个赠款期间，专门用于衰老生物学的资金规模增加了两倍，同时还创造了令人印象深刻的出版物记录，如在《自然》和《科学》杂志上发表的124篇论文和评论，每个E-NSC研究人员平均约有6篇协作论文(与其他E-NSC成员一起)，并积极招募和‘转化’25名不是第一次提交的成员的E-NSC成员。我们的成员现在包括内部成员(52名)和外部成员(11名)，以及支持与布朗大学(5名)调查人员组成的“迷你国家安全委员会”。其他资源对E-NSC的成功也非常重要，包括大型老龄计划项目、正在进行的由NIH资助的爱因斯坦老龄(T32)培训补助金、关于老龄生物学的补充性研究生课程，以及爱因斯坦的格伦人类老龄生物学中心。E-NSC的活动受到补充机构资金的影响；该中心发放了18笔试点和可行性赠款，取得了良好的结果。三个研究资源核心为150多名研究人员提供服务，以负担得起的价格提供具有可靠质量控制的最先进服务。 E-NSC的目标是： 1)通过为我们的三个研究资源核心提供最先进和独特的新技术，加强和扩大正在进行的衰老研究的基础生物学： A)衰老核心的蛋白质稳定性(PAC，安娜·玛丽亚·库尔沃博士)； B)衰老核心的时间生物学、能量/代谢(CEAC，Nir Barzilai博士和Derek Huffman博士)； C)衰老核心的高级基因组学(AGAC，Jan Vijg博士)。 2)行政核心(Barzilai博士)通过系列讲座、小型务虚会和出席国家安全委员会全国会议实施和管理丰富活动，并将继续开发潜在的区域和/或国家资源。 3)通过一个研究发展核心(Yousin Suh博士)为衰老生物学研究的新研究人员提供支持和合适的环境，该核心将为应得的研究人员提供P&F奖。

DESCRIPTION (provided by applicant): This is the first competitive renewal for the transformative Einstein Nathan Shock Center (E-NSC). During the first grant period, funding exclusively for biology of aging tripled in size, and was accompanied by an impressive publications record E-NSC members as exemplified in 124 papers and reviews in Nature and Science-journals, a staggering average of approximately 6 collaborative papers (with other E-NSC members) per E-NSC investigator and the proactive recruitment and 'conversion' of 25 members to the E-NSC who were not members for the first submission. Our membership now includes internal (52) and external (11) members as well as support for a 'mini-NSC' with Brown University (5) investigators. Other resources are also highly important for E-NSC success, including large aging Program Projects, an ongoing NIH-funded Einstein Aging (T32) training grant, a complementary graduate course on the Biology of Aging, and the Glenn Center for Biology of Human Aging at Einstein. Activities of the E-NSC were leveraged by supplemental Institutional funding; the Center awarded 18 pilot and feasibility grants, with good outcomes. The three Research Resource Cores provided services to over 150 investigators, offering state-of the art services with dependable quality control at an affordable price. The aims of the E-NSC are: 1) To enhance and expand ongoing basic biology of aging research by providing state of the art and unique new technologies for our three Research Resource Cores: a) Proteostasis of Aging Core (PAC, Dr. Ana Maria Cuervo); b) Chronobiosis, Energetics/Metabolism of Aging Core (CEAC, Drs. Nir Barzilai and Derek Huffman); c) Advanced Genomics of Aging Core (AGAC, Dr. Jan Vijg). 2) The Administrative Core (Dr. Barzilai) implements and administers enrichment activities through a lecture series, mini-retreats and attendance at NSC national meetings, and will continue to develop potential regional and/or national resources. 3) To provide support and a suitable environment for new investigators in biology of aging research through a Research Development Core (Dr. Yousin Suh) that will provide P&F awards to deserving investigators.