Symposium on Hereditary Breast and Ovarian Cancers: Lessening the Burde

描述(申请人提供)：第二届遗传性乳腺癌和卵巢癌国际会议利用了2009年在巴里举行的会议的成功，来自大西洋两岸的研究人员齐聚一堂。在几个亮点中，将年轻研究人员纳入该计划和随后的合作活动是最值得注意的成就。目前的方案建立在这一成功的基础上，保留了一种会议结构，强调会议领导人和发言者的广泛地理分布，并使从提交的摘要中选择的发言具有可见性。事实上，将作出重大努力，宣传和提供旅行奖励，以配合来自全球学术机构的初级调查人员提交的多达20份精选材料。会议将涵盖新的干细胞和DNA修复生物学，预防和治疗乳腺癌和妇科癌症的局部和系统措施的发展，通过动物模型和全基因组分析揭示的遗传和环境相互作用，以及确定科学进步应用的障碍。主旨包括亨利·林奇的历史观和电台名人瓦莱丽·斯马尔多的妇女对疾病负担的观点；关于未来倡议的小组讨论将作为会议的适当结论。我们预计，这一计划结构，再加上我们在促进和跟踪合作的出现方面的“会议内”经验，将充分实现我们的计划目标，并导致在预防和治疗女性癌症方面取得进一步进展。 公共卫生相关性：相关性：在美国，乳腺癌和卵巢癌每年造成约6万人死亡。遗传性癌症虽然只占这些病例的10%，但在确定相关遗传特征和实施预防和监测措施方面走在了前列。因此，这次会议将对处理乳腺癌和卵巢癌各方面问题的工作人员产生兴趣。

DESCRIPTION (provided by applicant): This second international meeting on hereditary breast and ovarian cancer capitalizes on the success of the 2009 meeting held in Bari that brought together researchers from both sides of the Atlantic. Among several highlights, the incorporation of young researchers within the program and in subsequent collaborative activities was the most noteworthy accomplishment. The current program builds on this success preserving a meeting structure that emphasizes broad geographic distribution of session leaders and speakers, and gives visibility to presentations chosen from submitted abstracts. Indeed, a major effort will be placed in publicizing and in providing travel awards to accompany up to 20 selected submissions by junior investigators from academic institutions throughout the globe. Sessions will cover new stem cell and DNA repair biology, developments of local and systemic measures for the prevention and treatment of breast and gynecological cancers, genetic and environmental interactions revealed by animal models and genome-wide analyses, and identification of barriers to the application of scientific advances. Keynotes include a historical view by Henry Lynch and a woman's perspective on the burden of illness by radio personality Valerie Smaldone; a panel discussion on future initiatives will serve as an appropriate conclusion to the meeting. We anticipate that this program structure coupled with our 'within-meeting' experience in stimulating and following up on the emergence of collaborations will amply fulfill our program objectives, and lead to further advances in the prevention and treatment of women's cancers. PUBLIC HEALTH RELEVANCE: Relevance: Cancers of the breast and ovary account for approximately 60,000 deaths annually in the United States. Hereditary cancers, although only accounting for 10% of these occurrences, lead the way in the determination of relevant genetic characteristics and in the implementation of preventive and surveillance measures. Thus this meeting will be of interest to workers dealing with all aspects of breast and ovarian cancers.