Structure and Energetics in Mammalian Cells

描述(申请人提供)：本申请申请资助美国科学家参加哺乳动物细胞结构和能量学系统生物学会议，重点是了解整合细胞功能转变的结构和功能基础，这是肿瘤发展的特征。近年来，人们对能量代谢作为癌症表型的核心组成部分的关键作用的认识有了显着的提高。此外，癌细胞涉及结构-功能关系的重大转变，这表明整合细胞功能的根本重新排序。尽管在我们对驱动这些转变和相关转变的关系的理解上存在重大差距，但亚细胞结构事件及其能量和代谢影响的大部分详细知识都存在于没有密切参与以疾病为重点的研究的研究人员手中。基于这些考虑，将在英国曼彻斯特组织一次由英国生化学会赞助的国际会议，会议将汇集细胞功能结构和能量方面的专家研究人员，以及对细胞综合功能有重大定位的系统生物学研究人员，以及能够将这些观点放在疾病背景下的癌症研究人员。会议形式旨在以创新的方式加强讨论，促进来自不同背景和知识基础的研究人员之间的互动和合作，以促进和促进他们对导致癌症的整合细胞功能变化的理解做出贡献。这份申请是为了申请美国调查人员参加这次会议的旅行奖励。将鼓励来自不同研究领域的老牌研究人员提出申请，他们可以为讨论带来不同的观点，以及愿意突破现有范式并在疾病中整合细胞功能问题上开辟新前景的职业早期研究人员的申请。将特别强调促进女科学家的参与，并鼓励来自处境不利的少数群体的研究人员以及残疾调查人员的参与。 与公共卫生相关：有许多证据表明，向癌症表型的转变不能通过解除个别基因或途径的调控来充分描述，而是需要了解整合的细胞功能。哺乳动物细胞结构和能量系统生物学会议旨在将细胞功能结构和功能方面的专家科学家和对整合细胞功能感兴趣的系统生物学家与了解疾病过程的癌症研究人员聚集在一起。该申请要求为旅行奖励提供资金，以鼓励美国科学家参加这次会议并为其做出贡献，预计这次会议将为癌症研究领域带来新的视角，可能有助于改进疗法的开发。

DESCRIPTION (provided by applicant): This application requests funding for travel awards to US-based scientists to attend a conference on the Systems Biology of Structures and Energetics in Mammalian Cells, with a focus on understanding the structural and functional basis for the transitions in integrated cell functions that characterize the development of tumors. Recent years have witnessed a remarkable surge in the recognition of the critical role of energy metabolism as a central constituent of the cancer phenotype. In addition, cancer cells involve major transitions in structure-function relationships that indicate a fundamental re-ordering of the integrated cell function. Although there are major gaps in our understanding of the relationships that drive these and related transitions, much of the detailed knowledge of the subcellular structural events and their energetic and metabolic implications resides with investigators who are not intimately involved in the disease-focused research. Based on these considerations, an international conference will be organized in Manchester, UK, under the auspices of the Biochemical Society of Great Britain, which will bring together investigators who are experts on the structural and energetic aspects of cellular function with systems biology researchers who have a major orientation on integrated cell function and with cancer researchers who can put these perspectives in a disease context. The conference format aims at an innovative approach to enhance discussion and promote interactions and collaborations between investigators from very different backgrounds and knowledge bases, to facilitate and promote their contribution to the understanding of changes in integrative cell function that leads to cancer. This application is to request travel awards for US-based investigators to participate in this conference. Applications will be encouraged from established investigators from diverse areas of research who can bring different perspectives to the discussion, as well as from early career investigators who are willing to break through existing paradigms and open new vistas on the problem of integrating cell function in disease. Particular emphasis will be placed on facilitating the participation of women scientists and encouraging the participation of researchers from disadvantaged minorities as well as investigators with disabilities. PUBLIC HEALTH RELEVANCE: There is much evidence that the transition to the cancer phenotype cannot be adequately described by the deregulation of individual genes or pathways, but requires an understanding of integrated cell function. The conference on Systems Biology of Structures and Energetics in Mammalian Cells aims at bringing together scientists who are specialists in structural and functional aspects of cell function and systems biologist interested in integrative cell function with cancer researchers who understand the disease process. The application requests funding for travel awards to encourage participation of US-based scientists to participate in and contribute to this conference, which is expected to bring novel perspectives to the field of cancer research that may contribute to the development of improved therapies.