EPIGENETICS, CHROMATIN & TRANSCRIPTION

描述(由申请人提供) 本申请旨在为将于2011年7月31日至8月5日在科罗拉多州斯诺马斯举行的关于“表观遗传学、染色质和转录”的FASEB夏季会议寻求部分资金。这次会议是1991年以来每两年举行一次的非常成功的会议的延续。这次会议的主要目标是满足一个论坛的迫切需要，在这个论坛上，几个学科的前沿汇聚在表观遗传调控和疾病上，以审查这一不断增长的领域的关键发展，并培育和启发新的研究方向。一个关键的考虑是，表观遗传学研究涵盖了各种各样的子领域，而这次会议在努力将这些多个方面结合在一起方面是独一无二的。在这次会议上，结构、生化、遗传和系统方法的融合，以及对干细胞生物学、发育和疾病的关注，突显了将来自广泛不同学科的研究人员聚集在一起报告他们在这一动态领域的最新发现的好处。从一开始，FASEB染色质和转录会议就欢迎并促进了不同的研究方法，从而产生了令人兴奋和协同的陈述和讨论。研究人员现在将“表观遗传学”包括在标题中，以反映人们对持续的染色质调节状态在发育和疾病中的日益增长的兴趣。这次会议吸引了一个强大的国际定期与会者和演讲者群体，而且确实是FASEB最成功的会议之一。此外，为了扩大感兴趣的领域，调查人员还包括了一批新的发言者，以确保在这个充满活力的领域产生多样化和活力的想法。此外，他们打算通过从摘要中挑选更多的发言者，包括首席研究人员和博士后科学家，进一步使发言者群体多样化。会议的具体目标是：1)对染色质和表观遗传调控领域进行广泛和批判性的审查，包括调节转录的酶等传统主题。会议扩展到其他关键领域，例如大型复合体的新结构生物学、染色质的RNA调控、新技术(例如系统生物学)、重要的生理领域(例如干细胞和发育生物学)以及疾病领域(例如癌症、老龄化和环境影响)。2)通过介绍和热烈讨论新的突破，推动这一不断扩大的领域的前沿研究。(3)汇聚各级高级和初级科学家，鼓励广泛讨论，促进青年科学家的发展。 公共卫生相关性：这次会议的主要目标是聚集来自不同学科的研究人员，报告他们在表观遗传学、染色质和转录领域的最新发现。染色质调节影响细胞核中的每一个事件，从而影响细胞参与的每一个过程。染色质如何在保持其结构的同时提供足够的灵活性，以实现有效的交易，包括DNA复制、修复、重组和转录，这是一个令人着迷的领域，也是一个不断有显著发现的领域。因此，人们普遍认为，仍有巨大的见解和新的范式有待发现。这次会议将有助于快速推进以下方面的研究：染色质结构维持和遗传的基本机制，新的酶活性的作用，染色质事件对发育和环境信号的反应机制，以及茎和组织指定的问题以及这些问题在疾病状态下如何改变，如糖尿病、癌症和衰老。特别是，今年，研究人员在会议的标题中新加入了“表观遗传学”，以反映人们对作为发育和疾病状态基础的染色质结构变化的极大兴趣，在后一种情况下，这可能有助于通过“表观遗传疗法”来逆转或改善疾病状况。

DESCRIPTION (provided by applicant) This application seeks partial funding for a FASEB Summer Conference on "Epigenetics, Chromatin & Transcription", to be held July 31- August 5, 2011 in Snowmass, Colorado. This conference represents a continuation of a highly successful meeting that has met every two years since 1991. The major goal of this conference is to fulfill a critical need for a forum in which the forefront of several disciplines converging on epigenetic regulation and disease can meet to review key developments in this growing field, and to foster and inspire new research directions. One key consideration is that epigenetic research encompasses a wide diversity of sub-areas, and this meeting is unique in endeavoring to bring together these multiple aspects. The convergence of structural, biochemical, genetic, and systems approaches at this meeting, as well as focus on stem cell biology, development, and disease underscores the benefits of bringing together researchers from widely differing disciplines to report on their most recent findings in this dynamic field. From inception, the FASEB Chromatin and Transcription Conference has welcomed and fostered diverse research approaches resulting in exciting and synergistic presentations and discussions. The investigators now include "Epigenetics" in the title, to reflect the growing interest in persistent chromatin regulatory states in development and disease. This conference attracts a strong international group of regular attendees and speakers, and, indeed, is one of the most consistently successful FASEB meetings. In addition, to expand the interest area, the investigators have included a new cohort of speakers, to ensure a diversity and energy of ideas arising in this dynamic field. Further, they intend to further diversify the speaker group, by selecting additional speakers, both principal investigators and post-doctoral scientists, from abstracts. The specific objectives of the meeting are: 1) To provide an expansive and critical review of the field of chromatin and epigenetic regulation, including traditional topics such as the enzymes that regulate transcription. The meeting extends into other key areas, such as new structural biology of large complexes, RNA regulation of chromatin, novel technologies (e.g. systems biology), important physiological areas (e.g. stem cell and developmental biology), as well as disease areas (e.g. cancer, aging, and environmental impact). 2) To advance cutting-edge research in this expanding field, through presentation and lively discussion of novel breakthroughs. 3) To bring together senior and junior scientists of all ranks, encouraging wide- ranging discussions and promoting the development of young scientists. Public Health Relevance: The major goal of this conference is to bring together researchers from various disciplines to report on their most recent findings in the fields of epigenetics, chromatin and transcription. Chromatin regulation impacts on every event in the nucleus and thus every process in which a cell participates. How chromatin both retains its structure while providing sufficient flexibility to enable efficient transactions, including DNA replication, repair, recombination, and transcription is fascinating and an area of continued remarkable discoveries. Thus it is widely held that there are still huge insights and new paradigms to be uncovered. This conference will contribute to the rapid advancement of research on: the basic mechanisms by which chromatin structures are maintained and inherited, the role of novel enzyme activities, the mechanism by which events on chromatin respond to developmental and environmental signals, and questions of stem and tissue specification and how these are altered in disease states, such as diabetes, cancer, and aging. In particular, this year the investigators newly include "epigenetics" in the title of the conference, to reflect a greatly expanding interest in changes in chromatin structure that underlie development and disease states, and, in the latter case, that may be amenable to "epigenetic therapy" to reverse or ameliorate the disease condition.