2011 Nucleosides, Nucleotides, and Oligonucleotides GRC

描述(由申请人提供)：本提案请求部分支持将于2011年7月3-8日在RI纽波特的Salve Regina大学举行的关于核苷、核苷酸和寡核苷酸的会议，作为戈登研究会议系列的一部分。会议的广泛和长期目标是增加我们对核苷、核苷酸和寡核苷酸化学的理解。这些制剂作为诊断工具和治疗危及生命的疾病的药物的生物学意义，将补充化学及其在理解生物过程中的使用。本次会议的具体目标是召集9位讨论领袖主持9场会议。大会主席和副主席将对整个会议进行监督。将有21名演讲者代表核苷、核苷酸和寡核苷酸的化学和生物学的关键领域，以及10名学生口头陈述。该计划将有一次主旨演讲和八次会议，广泛讨论合成生物学、系统化学、DNA和RNA结构、基因表达的转录控制、作为治疗剂的核苷类似物、核苷酸受体、催化RNA和表观遗传学等当前问题。主旨演讲将由J·绍斯塔克(2009年诺贝尔奖)主讲。此外，两个晚上的海报会议将允许所有参与者为这些主题做出贡献。这次会议将为年轻的研究人员、妇女和少数民族提供许多机会，与该领域的高级领导人进行互动。这一应用的意义在于，戈登研究会议是专注于核苷、核苷酸和寡核苷酸的化学家和生物学家聚集在一起的唯一平台。核苷类似物通过不同的作用机制，对实体肿瘤和血液系统恶性肿瘤以及包括艾滋病在内的几种病毒疾病的治疗非常有效。核酸类似物如siRNA、miRNA、反义、催化RNA是药物开发中最令人兴奋的新领域。因此，这次会议具有非常重要的意义，因为它与健康有关。化学家和科学家之间的讨论将产生新的知识和发展新疗法的途径。除了成为疾病预测和诊断的主要工具外，寡核苷酸还作为新的工具广泛应用于表观遗传学、合成生物学和系统化学，将成为未来产生新药的重要技术。会议将聚焦于所有这些新领域，并将成为一个讨论论坛和交流平台，以产生新的知识和合作。 公共卫生相关性：有许多抗癌和抗病毒药物通过抑制参与核酸新陈代谢的酶起作用。核苷、核苷酸和寡核苷酸戈登研究会议的目标是帮助研究人员了解这一领域的最新发展。年轻的调查人员、妇女和少数族裔将有许多机会与该领域的高级领导人互动。这次会议将促进对一个重要的细胞代谢过程的更好的理解，并导致不同学科的科学家之间的合作，这可能导致未来的药物开发。

DESCRIPTION (provided by applicant): This proposal requests partial support for a meeting on Nucleosides, Nucleotides, and Oligonucleotides as a part of the Gordon Research Conference series to be held in Salve Regina University, Newport, RI from July 3 - 8, 2011. The broad and long term goal of the conference is to increase our understanding of the chemistry of nucleosides, nucleotides, and oligonucleotides. The biological significance of these agents as tools for diagnosis and as drugs for treatment of life-threatening diseases will complement the chemistry as well as their use in understanding biological processes. The specific aims of this meeting will be to convene nine discussion leaders to moderate nine sessions. Chair and vice-chair of the conference will supervise the whole conference. There will be 21 speakers who will represent critical areas of the chemistry and biology of nucleosides, nucleotides, and oligonucleotides and 10 oral student presentations. The program will have a keynote address and eight sessions that broadly address current issues in synthetic biology, systems chemistry, DNA and RNA structures, transcription control of gene expression, nucleoside analogues as therapeutic agents, nucleotide receptors, catalytic RNA and epigenetics. The key note lecture will be given by J Szostack (Nobel Prize, 2009). In addition, two evening poster sessions will permit all participants to contribute to these topics. The meeting will provide numerous opportunities for young investigators, women, and minorities to interact with senior leaders in the field. The significance of this application is that the Gordon Research Conference is the only platform where chemists and biologists who focus on nucleosides, nucleotides, and oligonucleotides come together. Nucleoside analogs, acting by diverse mechanisms, are highly effective for treatment of solid tumor and hematological malignancies and several viral diseases including AIDS. Nucleic acids analogs as siRNA, miRNA, antisense, catalytic RNA belong to the most exciting new areas in drug development. This conference is therefore highly significant regarding its health relatedness. The discussions among chemists and scientists will generate new knowledge and avenues for development of novel therapeutics. Besides becoming major tools for prognosis and diagnosis of diseases, oligonucleotides are widely used as new tools in epigenetics, synthetic biology and systems chemistry, which will become important technologies for generating new drugs for the future. The conference will focus on all these new areas and will be a discussion forum and an exchange platform for generating new knowledge and collaborations. PUBLIC HEALTH RELEVANCE: There are numerous anticancer and antiviral drugs that work by inhibition of enzymes involved in nucleic acid metabolism. The goal of the Nucleoside, Nucleotide & Oligonucleotide Gordon Research conference is to aid investigators learn about the newest developments in this field. There will be numerous opportunities for young investigators, women, and minorities to interact with senior leaders in the field. This conference will promote an enhanced understanding of an important cellular metabolic process and lead to collaborations amongst scientists of various disciplines that could lead to future drug development.