Beyond GWAS: the next 10 years of InterLymph

描述（由申请人提供）：这是国际淋巴瘤流行病学联盟（“InterLymph”）的第10届年会，该联盟是一个由流行病学家、统计学家、遗传学家、基础科学家和临床医生组成的国际组织，旨在阐明几种非霍奇金淋巴瘤和相关肿瘤（霍奇金淋巴瘤和多发性骨髓瘤）的病因。这些研究者召开会议，以解决原因不明和非霍奇金淋巴瘤发病率每年大幅增加的问题，以及分类频繁变化引起的混乱，亚组之间广泛未认识到明确的病因差异，可用的暴露测量不足，个体研究者面临的限制，以及跨国际边界汇总结果的需要，无论是统计力量还是全面覆盖。工作亚组解决由临床亚组和病因学假设定义的特定问题。审查和更新合作项目，交流研究结果，开展新的合作研究，并制定政策。每次会议的方案和主题由一个组织委员会与会议主持人合作制定，会议主持人是一项成员研究的调查员，并将相关的当地专家作为外部发言人聚集在一起。会议地点通常在北美和其他成员研究地点之间轮换。2011年会议将由意大利卡利亚里大学的Pierluigi Cocco教授主持，会议日程将由组委会主席（PI Wendy Cozen博士）与其他组委会成员（克莉丝汀斯基博拉、保罗·博菲塔和亨里克·贾尔格里姆博士）沿着制定。主题是“超越GWAS：国际淋巴组织的未来10年”。我们计划回顾所有已完成的全基因组关联研究结果，促进新的协作基因-环境，基因-基因和环境-环境相互作用的发展，专注于亚型特异性结果和潜在的翻译问题。除了工作组会议外，还将举办演讲者计划，包括主要客座演讲者，以及针对初级调查员和学生的海报会议。预计将有大约100名与会者，其中包括来自18个机构的研究人员，他们在多个大陆完成或正在进行淋巴瘤流行病学研究，其中包括来自四大洲的16，000多例病例和16，000例对照。 公共卫生相关性：非霍奇金淋巴瘤是一组不同的恶性肿瘤，具有共同的血液学起源，但具有不同的生物学，流行病学和临床特征。在过去的四、五十年里，发病率以每年3-4%的速度增长，甚至不包括艾滋病流行造成的更大增长。因此，这些肿瘤构成了一个主要的癌症亚组，病因不明，目前没有预防手段。这将是第十次会议的国际研究小组（国际淋巴瘤流行病学联盟（“InterLymph”）召开，以克服淋巴瘤调查的许多困难：频繁的病理重新分类，多种亚型，困难的暴露分类，和多样化的研究方法。正如该小组以前的会议一样，这次会议将是一次思想交流的结合，与发言者，外部主要发言者和海报，以及一系列合作科学家的工作会议，他们汇集了资源，通过对已知和可疑的环境原因，遗传基础，以及它们之间的相互作用。

DESCRIPTION (provided by applicant): This is to be the 10th annual meeting of the International Lymphoma Epidemiology Consortium ("InterLymph"), an international group of epidemiologists, statisticians, geneticists, basic scientists, and clinicians collaborating to elucidate the causes of the several varieties of non- Hodgkin lymphoma and related neoplasms (Hodgkin lymphoma and multiple myeloma). These investigators convene to address the unknown causation and the substantial annual increase in incidence of non-Hodgkin lymphoma, and the confusion arising from the frequent changes in classification, the widespread non-recognition of clear etiologic differences between subgroups, the inadequacy of available exposure measurement, the constraints faced by individual investigators, and the need to pool results across international boundaries, both for statistical power and comprehensive coverage. Working subgroups address specific issues defined by clinical subgroup and etiologic hypotheses. Collaborative projects are reviewed and updated, findings exchanged, new collaborative studies developed and policies formulated. The program and theme of each meeting is developed by an organizing committee working with the meeting host, who is an investigator in one of the member studies, and who brings together pertinent local experts as outside speakers. The meeting site usually rotates between North America and the other member study locations. The 2011 meeting will be hosted by Professor Pierluigi Cocco from the University of Cagliari in Italy, and the program will be developed by the Chair of the Organizing Committee (Dr. Wendy Cozen, PI), along with other members of the Organizing Committee (Drs. Christine Skibola, Paolo Boffetta, and Henrik Hjalgrim). The theme is "Beyond GWAS: the next 10 years of InterLymph". We plan to review all completed genome-wide association study results, promote the development of new collaborative gene-environment, gene-gene, and environment-environment interactions, concentrating on subtype-specific results and potential translational issues. In addition to the working-group sessions, there will be a program of speakers, including key guest speakers, and poster sessions for junior investigators and students. Approximately 100 attendees are expected and will include investigators from 18 institutions with completed or ongoing epidemiologic studies of lymphoma on multiple continents with over 16,000 cases and 16,000 controls from four continents. PUBLIC HEALTH RELEVANCE: Non-Hodgkin lymphomas are a diverse group of malignancies with a common hematological origin but diverse biological, epidemiological, and clinical characteristics. Increasing in incidence over the past four or five decades at rates of 3-4% annually, even excluding the larger increase attributable the AIDS epidemic. These neoplasms therefore constitute a major cancer subgroup of obscure etiology and no current means of prevention. This will be the tenth meeting of an international group of investigators (the International Lymphoma Epidemiological Consortium ("InterLymph") convened to overcome the many difficulties of lymphoma investigation: frequent pathologic reclassification, multiple subtypes, difficult exposure classification, and diverse research methodologies. As the previous meetings of this group have been, this meeting will be a combination of idea exchange, with speakers, outside key speakers, and posters, and a series of working sessions of collaborating scientists, who have pooled resources to mount a collective attack on the ignorance concerning the causation of these malignancies with studies of known and suspected environmental causes, the genetic underpinnings, and the interactions between them.