The 6th International Leukocyte Signal Transduction Workshop

描述（由申请人提供）：适当的免疫应答取决于不同白细胞和其他细胞类型及其可溶性产物之间的复杂相互作用，以及许多受体之间的广泛串扰，其干扰激活信号，导致诱导细胞特异性基因程序、分化、增殖和获得效应子功能。失调的免疫反应可能导致有害的结果，自身免疫性疾病的发展就是一个很好的例子。导致炎症和自身免疫发展的异常机制已在很大程度上通过小鼠的遗传操作得到阐明，这导致了对潜在信号传导机制的重要见解。因此，在确定的步骤中对信号传导途径的遗传改变可以预防或诱导自身免疫和其他免疫性疾病的发展。然而，小型科学会议，允许密集的互动和富有成效的讨论，并在同一时间，汇集了科学家的白细胞信号通路的基本方面和这些途径的临床意义（包括相关的疾病模型）是远远和很少之间。 要求提供资金，以支持将于2011年6月5日至10日在希腊克里特岛举行的题为“第六届国际白细胞信号转导研讨会”的国际会议。这是自2000年以来举行的一系列类似会议中的第六次。即将到来的会议计划，约有80-90名预期参与者，将汇集从事以下工作的科学家：i）白细胞信号通路的基本方面; ii）动物疾病模型和这些通路的临床意义; iii）相关的尖端技术。受邀教师由约26名国际知名科学家组成，他们是相关研究领域的公认专家。处于职业生涯早期形成阶段的科学家将优先参与和介绍。 研讨会的具体目标是：1。通过关注自上次（第5次）研讨会以来产生的重大新发现和发现，扩展并继续之前五次高效的白细胞信号转导研讨会。 2.汇集了国际知名的科学家，他们是白细胞信号转导和白细胞信号通路的疾病影响方面的专家，例如，炎症，自身免疫和感染性疾病，以介绍和讨论最新的相关研究。 3.让科学家在职业生涯的早期阶段，即，博士后研究员和研究生，特别是那些代表少数群体或来自发展中国家的博士后研究员和研究生，有机会介绍自己的工作，并受益于与领先科学家的密切、一对一的互动，从而提供一种教育经验和致力于科学研究事业的动力。 组织者预计，本次研讨会将提供有关所涵盖主题的最新信息，并将促进从事白细胞信号传导基本方面工作的科学家与研究动物或人类炎症和自身免疫性疾病的科学家之间的想法和合作。 公共卫生相关性：要求为题为“第六届国际白细胞信号转导研讨会”的会议提供财政支持。本次研讨会是2000年启动的一系列富有成效的会议中的第六次，将于2011年6月5日至10日在希腊克里特岛举行，将有来自不同国家的约80-90名与会者参加，其中包括由约26名国际知名演讲者组成的杰出教师，他们都是各自研究领域的公认领导者。会议的中心焦点将是免疫系统中不同细胞类型获得针对入侵微生物产生有效免疫防御反应的能力的生化和分子机制，以及这些途径的异常如何导致自身免疫等免疫系统疾病和炎症。所要求的支助将主要用于支付登记和生活费用，并高度优先考虑青年科学家和代表性不足群体的个人。

DESCRIPTION (provided by applicant): A proper immune response depends on complex interactions between different leukocytes and other cell types and their soluble products, and on an extensive crosstalk among many receptors, which transduce activation signals leading to induction of cell-specific gene programs, differentiation, proliferation, and acquisition of effector functions. A deregulated immune response can lead to harmful results, the development of autoimmune diseases being a prime example. Aberrant mechanisms that lead to development of inflammation and autoimmunity have been elucidated to a large degree by the genetic manipulation of mice, which led to significant insights into the underlying signaling mechanisms. Thus, genetic alteration of signaling pathways at defined steps can prevent or induce the development of autoimmunity and other immunological diseases. Nevertheless, small scientific meetings that allow intensive interactions and fruitful discussions and, at the same time, bring together scientists working on fundamental aspects of leukocyte signaling pathways and on the clinical implications of these pathways (including relevant disease models) are far and few between. Funds are requested to support an international conference entitled "The 6th International Leukocyte Signal Transduction Workshop" to be held in Crete, Greece, on 6/5-10/11. This is the 6th in a series of similar meetings, which were held since 2000. The program for the upcoming meeting, with ~80-90 anticipated participants, will bring together scientists working on: i) fundamental aspects of leukocyte signaling pathways; ii) animal disease models and clinical implications of these pathways; and iii) relevant cutting edge technologies. The invited faculty consists of ~26 internationally known scientists who are recognized experts in relevant research areas. Scientists at the early, formative stage of their career will be given priority in participation and presentation. The Specific Aims of the Workshop are: 1. Extend and continue five previous, highly productive Leukocyte Signal Transduction Workshops, by focusing on major new discoveries and findings generated since the previous (5th) Workshop. 2. Bring together internationally known scientists, who are experts in leukocyte signal transduction and the disease implications of leukocyte signaling pathways to, e.g., inflammation, autoimmunity, and infectious disease, in order to present and discuss the most up-to-date relevant research. 3. Give scientists at an early stage of their career, i.e., postdoctoral research fellows and graduate students, particularly those representing minority groups or coming from developing countries, an opportunity to present their own work and to benefit from close, one-on-one interactions with leading scientists, thereby providing an educational experience and a motivation to commit themselves to a scientific research career. The Organizers anticipate that this Workshop will provide most up-to-date information on the covered topics, and will stimulate sharing of ideas and collaborations between scientists working on basic aspects of leukocyte signaling and those studying animal or human inflammatory and autoimmune diseases. PUBLIC HEALTH RELEVANCE: Financial support is requested for a conference entitled "The 6th International Leukocyte Signal Transduction Workshop". This Workshop, the 6th in a series of highly productive meetings initiated in 2000, will be held on June 5-10, 2011 in Crete, Greece, and will be attended by ~80-90 participants from different countries, including a distinguished faculty of ~26 internationally known speakers, who are all recognized leaders in their respective areas of research. The central focus of the meeting will be the biochemical and molecular mechanisms through which different cell types in the immune system acquire the ability to mount effective immune defense responses against invading microbes, and how aberrations in these pathways can lead to immune system diseases such as autoimmunity and inflammation. The requested support will mostly be used to defray the costs of meeting registration and subsistence costs, with high priority being given to young scientists and individuals from underrepresented groups.