2011 Bones & Teeth Gordon Research Conference

描述（由申请人提供）：戈登骨骼和牙齿研究会议旨在为来自不同学科的不同水平和成就的科学家提供一个论坛，展示和讨论骨骼和牙齿进化，发育，衰老和疾病领域的前沿研究成果，想法和假设，特别强调遗传，分子和细胞机制以及修复和再生的潜力。该研究会议于1954年作为年度会议成立，自1989年以来每两年举办一次；它是2011年由GRC组织的150多个会议的一部分，GRC以组织高质量的前沿科学会议而闻名于世。2009年的会议非常成功，获得了与会者的高绩效评价。2011年骨骼与牙齿GRC将于2011年6月19日至24日在瑞士Les diableets会议中心举行。该计划邀请国际公认的领导人作为演讲和讨论的领导者，并围绕“骨骼和牙齿生物学和疾病的进化和发展机制”的主题组织。在理解进化和发育机制方面的最新进展为确定骨和牙齿主要疾病的新治疗靶点提供了信息，并为基于干细胞的再生和修复方法的发展提供了概念基础。基因组技术的最新进展和高通量测序使对种群适应性进化变化的遗传研究成为可能，这与对人类疾病相关突变的研究和对动物模型的反向遗传分析相辅相成。这些研究为深入了解骨和牙齿发育和体内平衡的详细机制打开了大门，并可能加速将基础研究成果转化为临床干预措施。在本次会议的历史上，第二次，戈登研究研讨会将于6月18日至19日由初级研究人员围绕“骨和牙齿发育和再生中的细胞生态位微环境”的主题组织。研讨会的方案以两名高级研究员（由前一届研讨会的参与者选出）以指导身份参加为特色，目的是(a)允许学员（研究生和博士后）介绍和接受他们正在进行的研究项目的反馈，(b)为学员之间就发展和再生机制进行深入讨论提供一个论坛，为参加随后的戈登研究会议做准备。(c)促进学员之间的联系，并鼓励与指导教师讨论研究机会和职业选择。我们期待2011年骨与牙GRS/GRC将促进研究数据、思想、试剂和方法的国际交流；促进新的合作；促进研究生和博士后交流；帮助确定新的研究方向，提高骨骼和牙科研究的质量和临床影响。

DESCRIPTION (provided by applicant): The Gordon Research Conference on Bones & Teeth is designed to provide scientists at different levels of training and accomplishments and from a wide range of disciplines, with a forum for presentation and discussion of cutting-edge research findings, ideas and hypotheses in the areas of bone and tooth evolution, development, aging and disease, with particular emphasis on genetic, molecular and cellular mechanisms and potential for repair and regeneration. Established as an annual meeting in 1954, this research conference has been held every 2 years since 1989; it is part of over 150 conferences that will be organized in 2011 by the GRC, known internationally for organizing meetings of high-quality, cutting-edge science. The meeting in 2009 was extremely successful and received a High Performance rating by the participants. The 2011 GRC on Bones & Teeth will be held June 19-24, 2011, at Les Diablerets Conference Center, Switzerland. The program features internationally recognized leaders as speakers and discussion leaders and is organized around the theme of "Evolutionary and developmental mechanisms of skeletal and tooth biology and disease". Recent progress in understanding evolutionary and developmental mechanisms is informing efforts to identify novel therapeutic targets in major diseases of bones and teeth and provides the conceptual basis for development of stem cell-based methods for regeneration and repair. Genetic studies of adaptive evolutionary change in populations, made possible by recent advances in genome technologies and high throughput sequencing complement studies of disease-associated mutations in humans and reverse genetic analyses of animal models. These studies open doors to new insights into detailed mechanisms of bone and tooth development and homeostasis and they are likely to accelerate the translation of basic research findings into clinical interventions. For the second time in the history of this conference, a pre- conference Gordon Research Seminar will be organized June 18-19 by junior investigators around the theme of "Cell niche microenvironments in bone and tooth development and regeneration". The program of the seminar, featuring participation of two senior investigators (selected by the participants of the previous seminar) in a mentoring capacity, is aimed at (a) allowing trainees (graduate students and postdoctoral fellows) to present and receive feedback on their ongoing research projects, (b) providing a forum for intense discussion among trainees of developmental and regenerative mechanisms, in preparation for participation in the subsequent Gordon Research Conference, and (c) facilitating networking among trainees and stimulating discussion of research opportunities and career options with the mentoring faculty. We anticipate that the 2011 GRS/GRC on Bones & Teeth will stimulate international exchange of research data, ideas, reagents and methods; promote new collaborations; facilitate graduate student and postdoctoral exchange; help define new research directions and increase quality and clinical impact of skeletal and dental research.