2009 Gordon Research Conference on Cartilage Biology and Pathology

2009年戈登软骨生物学和病理学研究会议

• 批准号: 7672681
• 负责人: BJORN REINO OLSEN
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2009-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7672681
• 关键词: Adolescence; Adult; Affect; Aging; Biochemistry; Biology; Birth; Bone Marrow; Bone Tissue; Brain; Cartilage; Cartilage Diseases; Cell physiology; Cessation of life; Childhood; Complex; Degenerative Disorder; Degenerative polyarthritis; Development; Diagnosis; Discipline; Disease; Epiphysial cartilage; Extracellular Matrix; Future; Genes; Genetic; Goals; Growth; Growth Disorders; Interdisciplinary Communication; Interdisciplinary Study; Joints; Length; Modeling; Molecular; Molecular and Cellular Biology; Mutation; Natural regeneration; Orthopedics; Participant; Pathology; Postdoctoral Fellow; Predisposing Factor; Prevention; Quality of life; Research; Scientist; Series; Shock; Skeletal Development; Skeleton; Structure; Switzerland; Therapeutic; Time; Tissue Engineering; Tissues; Vertebral column; aging population; bone; cranium; graduate student; improved; interest; knowledge base; long bone; meetings; posters; prevent; programs; repaired; skull base; stem cell biology; success; symposium; vertebra body

DESCRIPTION (provided by applicant): This is a request for support of the fourth meeting in a highly successful series of Gordon Research Conferences on Cartilage Biology and Pathology, to be held at the Les Diablerets, Switzerland, June 7-12, 2009. Building on the success of the previous conferences, the meeting brings together outstanding senior and junior scientists and advanced graduate students and postdoctoral fellows for a 4.5 -day program of formal presentations, informal discussions and interactions and poster presentations. The participants share an interest in cartilage biology and pathology but represent a broad range of disciplines, including developmental and evolutionary biology, extracellular matrix biochemistry, cell and molecular biology, mechanobiology and tissue engineering, pathology, genetics, and orthopedics. Cartilage is a remarkable tissue that has several crucial functions. During skeletal development, models of the future bones are mostly made of cartilage. By a complex series of cellular processes these cartilage models are replaced by bone marrow and bone tissue, except towards the ends where a region of cartilage remains as growth plate cartilage, and at the very end, where a layer of cartilage serves as a slippery, shock-absorbing structure to allow bones to freely move where they meet in joints. Finally, a shock-absorbing and elastic layer of specialized cartilage between the vertebral bodies in the spine allows bending and twisting of the body. Growth plate cartilage in long bones and thin layers of cartilage between bones at the base of the skull are crucial for the increase in length of long bones during childhood and adolescence and the enlargement of the skull needed to accommodate the growing brain. When cartilage fails the consequences can be severe, ranging from death around birth to reduced growth of the skeleton or degenerative joint and spine disease in the aging adult. Several decades of research into cartilage and its disorders have led to identification of predisposing factors and cellular mechanisms of disease. Great strides have also been made in the understanding of genes and molecular mechanisms that regulate formation of cartilage-forming cells, the functions of growth plate cartilage and the formation of joints. At the same time advances in stem cell biology and tissue engineering is opening the door to the possibility that degenerating cartilage can one day be repaired or stimulated to regenerate. However, much remains to be understood before knowledge-based therapeutic strategies can be developed to prevent or slow down progression of osteoarthritis and degenerative changes in the spine, treat the consequences of mutations that affect growth plate function or repair/regenerate defective cartilage. The aim of the meeting is to stimulate interdisciplinary research to advance progression towards these goals.

说明（由申请人提供）：这是对将于 2009 年 6 月 7 日至 12 日在瑞士莱迪亚布勒雷举行的一系列非常成功的戈登软骨生物学和病理学研究会议第四次会议的请求。在之前会议成功的基础上，本次会议汇集了杰出的高级和初级科学家以及高级研究生和博士后研究员，进行为期 4.5 天的正式演讲、非正式演讲和非正式演讲。 讨论和互动以及海报展示。参与者对软骨生物学和病理学都有共同的兴趣，但代表了广泛的学科，包括发育和进化生物学、细胞外基质生物化学、细胞和分子生物学、机械生物学和组织工程、病理学、遗传学和骨科。软骨是一种非凡的组织，具有多种重要功能。在骨骼发育过程中，未来骨骼的模型大多由软骨制成。通过一系列复杂的细胞过程，这些软骨模型被骨髓和骨组织所取代，除了在末端，软骨区域保留为生长板软骨，在最末端，软骨层充当光滑的减震结构，允许骨骼在关节中相遇的地方自由移动。最后，脊柱椎体之间的特殊软骨的减震和弹性层允许身体弯曲和扭转。长骨中的生长板软骨和颅骨底部骨头之间的薄层软骨对于儿童和青春期长骨长度的增加以及容纳大脑生长所需的颅骨增大至关重要。当软骨失效时，后果可能很严重，从出生时死亡到骨骼生长减缓或老年人出现退行性关节和脊柱疾病。几十年来对软骨及其疾病的研究已经确定了疾病的诱发因素和细胞机制。在对调节软骨形成细胞形成、生长板软骨功能和关节形成的基因和分子机制的理解方面也取得了长足的进步。与此同时，干细胞生物学和组织工程的进步为退化软骨有一天可以修复或刺激再生打开了大门。然而，在开发基于知识的治疗策略来预防或减缓骨关节炎和脊柱退行性变化的进展、治疗影响生长板功能的突变后果或修复/再生有缺陷的软骨之前，还有很多事情需要了解。会议的目的是刺激跨学科研究，以推动实现这些目标。