Interdisciplinary Training in Genes and the Environment

描述(由申请人提供) 哈佛大学公共卫生学院(HSPH)的基因与环境跨学科培训计划将满足对训练有素的科学家的迫切需求，这些科学家了解并致力于分子和环境暴露生物学以及统计和计算方法交叉领域的尖端研究。培训计划将有30名有成就和经验丰富的多学科教员积极参与，其中包括环境健康科学家、分子生物学家、分子流行病学家、计算生物学家、生物统计学家和生物信息学家。我们提议的培训计划的两个相互关联的目标是：培养真正的合作伙伴，能够从事方法学研究，这些研究的动机是并帮助解决人类环境暴露和复杂疾病的遗传易感性研究中出现的困难分析问题；鼓励跨学科研究，特别是在遗传学和各种“组学”方面的研究，这些研究产生于实验室和人口科学中表征与环境暴露相关的生物活动的新方法。受训者将是HSPH的博士后学生和博士后研究员，他们是环境卫生、流行病学、生物统计学和遗传学和复杂疾病系的博士后研究员，这些系将共同管理这笔拨款。该计划建议为3名博士前学生提供初步支持，并在2年级增加2名实习生，在3年级增加3名实习生，以使每年总共8名博士前学生进入该计划(3-8年级)。该计划还计划支持每年培训一名博士后研究员。这些博士后实习生将拥有与暴露生物学/环境卫生科学或基因组学/蛋白质组学计算领域相关的高级学位(博士、医学博士、医学博士或其他博士学位)，并将对交叉培训研究经验特别感兴趣。基因与环境跨学科培训计划的所有受训人员将获得一个在基因组学、环境健康科学和定量方法方面获得同等技能的绝佳机会，以便在人类基因与环境的跨学科研究中担任领导角色，最终目标是在制定有效的疾病预防和干预策略方面服务于公众健康利益。

DESCRIPTION (provided by applicant) The Interdisciplinary Training in Genes and the Environment program at the Harvard School of Public Health (HSPH) will address the critical need for well-trained scientists who have an understanding of, and commitment to, cutting-edge research at the intersection of molecular and environmental exposure biology, and statistical and computational methods. The training program will involve active participation by 30 accomplished and experienced multidisciplinary faculty members, including environmental health scientists, molecular biologists, molecular epidemiologists, computational biologists, biostatisticians and bioinformaticians. The two interrelated goals of our proposed training program are: To train true collaborative partners able to pursue methodological research that is motivated by, and helps to solve, difficult analytic issues that arise in studies of human environmental exposures and genetic susceptibility to complex diseases; To encourage interdisciplinary research, especially in genetics and the various "omics" arising from new methodologies for characterizing biological activity associated with environmental exposures in laboratory and population sciences. Trainees will be pre-doctoral students and post-doctoral fellows at HSPH in the Departments of Environmental Health, Epidemiology, Biostatistics, and Genetics and Complex Diseases, which will jointly administer the grant. The program proposes initial support for 3 pre-doctoral students with 2 additional trainees in year 2 and 3 additional trainees in year 3 to bring an annual total of 8 pre-doctoral students into the program (year 3-8). The program also plans to support training of one post-doctoral fellow per year. These post-doctoral trainees will have an advanced degree (PhD, MD, MD-PhD or other doctoral degree) relevant to exposure biology/environmental health sciences or computational areas of genomics/proteomics and will have a specific interest in cross-training research experience. All trainees in the Interdisciplinary Training in Genes and Environment program will be provided an outstanding opportunity to become equally skilled in genomics, environmental health sciences and quantitative methods in order to attain leadership roles in interdisciplinary studies of human genes and the environment, with the ultimate goal of serving public health interests in developing effective disease prevention and intervention strategies.