Anxiety Vulnerability and Smoking Cessation

描述（由申请人提供）：本提案的主要目标如下：1. a.检验以下假设：与较低的焦虑敏感度（AS）相比，具有较高特征的吸烟者在自我指导戒烟尝试中的成功率较低，指标为：（1.a.1）首次戒烟时间较短;（1.a.2）戒烟后1周、2周、4周和12周的戒烟率较低。1.b.检验AS与吸烟失效/复吸之间的关联由特定情绪和基于吸烟的过程介导的假设，包括：（1.b.1）戒烟尝试期间的负面情绪强度水平较高;（1.b.2）戒烟尝试期间的尼古丁戒断症状强度水平较高。公共卫生相关性：本提案填补了吸烟精神病学文献中所需的临床和理论相关空白，如最近由当前NIMH吸烟精神脆弱性报告所支持的（Ziedonis等人，出版中）。事实上，拟议的研究结果将直接告知AS吸烟模型，并更普遍地作为特定焦虑相关过程如何维持吸烟行为的说明。拟议的调查代表了一项旨在了解吸烟失效和复吸机制的研究计划的临床意义和创新测试。

DESCRIPTION (provided by applicant): The primary objectives of the current proposal are as follows: 1.a. To test the hypothesis that smokers characterized by higher compared to lower Anxiety Sensitivity (AS) will demonstrate less success in a self-guided cessation attempt, as indexed by: (1.a.1) Shorter time to first smoking lapse; (1.a.2) Lower point-prevalence abstinence at one, two, four, and 12 weeks post-quit date. 1.b. To test the hypothesis that the association between AS and lapse/relapse to smoking is mediated by the specified emotion and smoking-based processes, including: (1.b.1) Greater levels of negative affect intensity during the cessation attempt; (1.b.2) Greater levels of nicotine withdrawal symptom intensity during the cessation attempt. PUBLIC HEALTH RELEVANCE: The present proposal fills a needed clinically- and theoretically-relevant gap in the smoking- psychiatric literature, as recently espoused by the current NIMH smoking-psychiatric vulnerability report (Ziedonis et al., in press). Indeed, results of the proposed study will directly inform AS-smoking models, and serve more generally as an illustration of how specific anxiety-related processes serve to maintain smoking behavior. The proposed investigation represents a clinically significant and innovative test for a program of research aimed at understanding the mechanisms underlying smoking lapse and relapse.