CLINICAL TRIAL: ADJUNCTIVE TREATMENT WITH DIVALPROEX OR RISPERIDONE IN CHILDREN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目通过一项多中心随机对照试验，采用双模拟药物给药，比较利培酮和丙戊酸盐两种药物在减少对兴奋剂单药治疗和行为干预反应明显不足的儿童中与兴奋剂治疗联合使用时的攻击行为方面的疗效、耐受性和获益寿命。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project compares, via a multisite randomized controlled trial with double-dummy medication administration, the efficacy, tolerability, and longevity of benefit of two agents, risperidone and valproate, in diminishing aggressive behavior when used adjunctively with stimulant treatment among children who experience demonstrably inadequate response to stimulant monotherapy and behavioral intervention.