AUTOIMMUNITY IN SISTERS OF SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) PATIENTS (SISSLE)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目标是招募400名35岁以下被诊断为系统性红斑狼疮的女性和至少一名未受影响的姐妹，对其进行纵向跟踪调查，每年抽血两年。目的是了解狼疮发生前的临床前生物学和免疫学事件，并确定可以预测临床疾病未来发展的生物标志物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal is to enroll 400 females diagnosed with systemic lupus erythematosus under the age of 35 and at least one unaffected sister to be followed longitudinally with questionnaires, annual blooddraws over two years. Aim is to understand the preclinical biological and immunologicalevents that preceed the development of lupus and to identify biomarkers that can predict future development of clinical disease.