IMPACT OF OBESITY AND PHYSICAL ACTIVITY ON ENDOMETRIAL CANCER GENESIS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在美国，肥胖的比例达到了史无前例的程度，65%的人口被定义为超重(BMI&GT；25)，30%的人口也被定义为肥胖(BMI&GT；30)。肥胖与许多不良健康后果有关，包括心血管疾病、糖尿病以及结肠癌、前列腺癌、胰腺癌、乳腺癌和子宫内膜癌(子宫内膜)。子宫内膜癌是美国女性第四大常见癌症，预计2005年将影响40,000名女性。大约40%的子宫内膜癌可能归因于肥胖，这被认为主要是由于脂肪细胞(脂肪细胞)通过雄激素转化为雌激素而增加了雌激素的产生。然而，并不是所有的肥胖女性都会患上子宫内膜癌，这表明除了雌激素增加之外，其他因素也一定在恶变过程中发挥了作用。肥胖女性的保护因素包括体育活动，但这种保护的确切机制仍不清楚。几乎没有关于超重和肥胖女性的脂肪细胞衍生因子或体力活动水平的前瞻性数据。因此，本研究的目的是前瞻性地收集接受子宫切除术的超重和肥胖绝经后妇女的基线体力活动测量、基线体重指数、基线激素水平、血脂样本和子宫内膜样本。收集后，我们将探索和确定患有和不患有子宫内膜癌的女性在脂肪或血液生物标记物或体力活动水平方面的差异。这项研究的目的是更好地确定绝经后超重和肥胖女性易患子宫内膜癌的危险因素，并确定与体力活动相关的任何保护性因素。这项研究的最终目标是能够预测并最终预防肥胖女性子宫内膜癌的发展。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity in the United States is reaching epic proportions with 65% of the population being defined as overweight (body mass index-BMI>25) and 30% also qualifying as obese (BMI>30). Obesity is linked to numerous adverse health consequences including cardiovascular disease, diabetes and cancers of the colon, prostate, pancreas, breast and endometrium (uterine lining). Endometrial cancer is the fourth most common cancer in women in the United States and is expected to affect 40,000 women in 2005. Approximately 40% of endometrial cancer may be attributed to obesity and this is thought to be primarily due to the increased estrogen production in adipocytes (fat cells) through the conversion of androgens to estrogens. Yet not all obese women will develop endometrial cancer suggesting that other factors aside from the increased estrogen must also play a role in the process of malignant transformation. Protective factors in obese women include physical activity but the exact mechanisms that underlie such protection remain poorly understood. Little prospective data exist on adipocyte derived factors or physical activity levels in overweight and obese women. Therefore, the purpose of this study is prospectively collect baseline physical activity measures, baseline body mass index, baseline hormonal levels, blood/fat samples, and endometrial samples from overweight and obese postmenopausal women who are undergoing hysterectomy. After collection, we will explore and identify differences in either fat or blood biomarkers or in physical activity levels in women with and without endometrial cancer. The goal of this research is to better define risk factors in postmenopausal overweight and obese women that predispose to endometrial cancer and to identify any protective factors that correlate with physical activity. The ultimate goal of the research is to be able to predict, and perhaps to eventually prevent, the development of endometrial cancer in obese women.