ANALYSIS OF BODY FAT USING MRI/MRS IN HEALTHY CHILDREN AND IN CYSTIC FIBROSIS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 MRI/MRS已被证明是一种快速、安全和非侵入性的测量肝脏脂肪含量的方法，并已被证明是肌肉脂代谢研究的重要工具。大多数先前关于体脂的MRI/MRS研究只包括成人，而据我们所知，先前的研究没有包括非超重的儿科人群。这项研究将评估健康的非超重儿童的肝脏和肌肉脂肪含量。在健康的非超重儿童中获得一系列正常值将有助于检测和评估其他疾病的肝脏和肌肉脂肪含量，例如囊性纤维化(CF)儿童。先前的一项研究是在费城儿童医院(CHOP)进行的，使用MRI/MRS来评估CF儿童的肝脏和肌肉脂肪堆积。解释这些数据的困难之一是，没有来自体重和年龄相似的健康儿童的标准数据。这项研究的目的是收集健康对照受试者的标准数据，以便与CF患者的结果进行比较。 在这项研究中，10岁或10岁以上的健康儿童将测量他们的身高和体重，并测量他们的腰围、手臂和腿的皮肤褶皱厚度。将进行肝脏和小腿肌肉的MRI/MRS检查。将计算体重指数(BMI)。 假设：正常体重儿童的体脂测量将与超重儿童的现有数据不同。正常儿童的数据需要与患有囊性纤维化等疾病的儿童的数据进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. MRI/MRS has been shown to be a fast, safe and non-invasive method for measuring fat content in the liver and has proven to be an important tool for muscle lipid metabolism studies. Most of the prior studies on MRI/MRS of body fat have included only adults and to our knowledge no prior study has included the non-overweight pediatric population. This study will assess the liver and muscle fat content in healthy non-overweight children. Obtaining a range of normal values in healthy non-overweight children will aid in detection and evaluation of liver and muscle fat content in other diseases, such as in children with Cystic Fibrosis (CF). A prior study was performed at Children's Hospital of Philadelphia (CHOP) using MRI/MRS to assess liver and muscle fat accumulation in children with CF. One of the difficulties in interpreting the data is that normative data from healthy children of a similar weight and age is not available. The purpose of this study is to collect the normative data from healthy control subjects for comparison with the results obtained in patients with CF. In this study, healthy children 10 years or older will have their height and weight, and size of their waist, arms and legs skin fold thicknesses measured. An MRI/MRS of the liver and lower leg muscle will be performed. Body mass index (BMI) will be calculated. Hypothesis: Body fat measurements in normal weight children will differ from existing data in overweight children. The data for normal children is required for comparison with data from children with diseases such as cystic fibrosis.