GENE TARGETS FOR INTRAVENTRICULAR HEMORRHAGE (IVH)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究正在研究为什么有些早产儿有脑室内出血（IVH），有些没有。IVH是脑内出血，最常见于早产儿。希望这项研究将有助于确定是否存在与IVH婴儿相关的遗传标记。 大约20%的婴儿在怀孕32周前（预产期前2个月）出生时发生脑室内出血。 医生已经证明，虽然一些病情严重，出生体重非常低的婴儿有IVH，但其他“同样患病的早产儿”没有。 为什么IVH可能发生在一些婴儿而不是其他人，我们还不完全了解。 有信息表明，寻找特定的遗传标记可以识别出脑出血高危人群。这项研究的目的是看看IVH婴儿是否可能有特定的遗传标记，而这些标记在没有IVH的婴儿中没有发现。 遗传标记可用于帮助确定某人是否有患某些疾病或病症的风险。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is looking at why some premature infants have intraventricular hemorrhage (IVH) and some do not. IVH is bleeding inside the brain and occurs most commonly in children born prematurely. It is hoped that this research will help to identify whether there is a genetic marker linked to babies with IVH. Intraventricular hemorrhage occurs in approximately 20% of babies born before 32 weeks of pregnancy (2 months before their due date). Doctors have shown that while some very ill, very low birth weight infants have IVH, other 'equally sick preterm infants' do not. Why IVH may occur in some babies and not others, we do not fully understand. There is information available suggesting that looking for specific genetic markers can identify adults who are at high risk for brain bleeds. The purpose of this study is to see if babies with IVH may have specific genetic markers that are not found in babies who do not have an IVH. Genetic markers may be used to help determine whether someone is at risk for developing certain diseases or conditions.