CHRONIC KIDNEY DISEASE IN CHILDREN PROSPECTIVE COHORT STUDY (CKID)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 具体目标： 1.找出导致儿童慢性肾脏病进展的新的和传统的肾脏疾病危险因素(例如，GFR下降) 2.描述肾功能下降对神经发育、认知能力和行为的影响。 3.明确传统心血管疾病危险因素和新的心血管疾病危险因素在进展性CKD中的流行和演变。 4.研究肾小球滤过率下降对生长发育的影响和生长障碍的治疗，并评估生长障碍对慢性肾脏病儿童发病率的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS: 1. Identify novel and traditional renal disease risk factors for the progression of CKD (e.g. decline of GFR) in children 2. Characterize the impact of a decline in kidney function on neurodevelopment, cognitive abilities, and behavior. 3. Identify the prevalence and evolution of traditional and novel cardiovascular disease risk factors in progressive CKD. 4. Examine the effects of declining GFR on growth and the treatment of growth failure, and to assess the consequences of growth failure on morbidity in children with CKD.