OBTAIN TISSUES AND ORGANS FOR HIV RESEARCH

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 描述（由申请人提供）： NDRI的人体组织和器官研究（HTOR）计划专门致力于为研究目的获取和提供人体组织。 这些组织和器官对于HTOR服务的绝大多数研究项目至关重要，该计划显然与促进人类健康有关。 HTOR的长期目标是增加可用于研究的人类研究组织的数量、多样性和质量。 组织的收集、制备和保存必须根据研究人员指定的方案进行，以便材料对科学家有用。 这些材料的获取需要一个广泛的国家网络，如医院病理和外科服务，眼科和组织库，以及器官采购组织。 HTOR独特的系统确保为定制方案采购的组织及时交付到适当的研究目的地。 运送给研究者的组织的数量、质量和多样性取决于三个关键变量：与HTOR合作的来源的数量和类型、HTOR的内部系统以及HTOR从研究者那里收到的研究请求的数量和类型。 拟议的资助期的具体目标集中在加强HTOR计划的这三个方面（来源，信息系统和研究人员）。 HTOR将努力提高现有来源的能力，并增加新的来源，以增加组织数量和多样性（具体目标1/来源）;升级HTOR的内部系统（计算机硬件、软件和数据管理），以改善数据采集和分析，并升级HTOR网站，以增加来源和研究人员对HTOR资源的访问（具体目标2/系统）;并与研究界密切合作，以满足现有的和新出现的人类研究组织的需求（具体目标3/研究人员）。 此外，HTOR将继续执行一项专门的计划，采购和分发艾滋病毒阳性组织（具体目标4），这一目标也与HTOR的长期目标一致。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): The Human Tissues and Organs for Research (HTOR) program of the NDRI is dedicated solely to accessing and providing human tissues for research purposes. These tissues and organs are essential for the great majority of research projects served by HTOR and the program is clearly relevant to advancing human health. HTOR's long-term objective is to increase the quantity, diversity, and quality of human research tissues available for research. The collection, preparation, and preservation of the tissues must be performed according to researcher-specified protocols for the materials to be useful to scientists. The acquisition of these materials requires an extensive national network of acquisition sites such as hospital pathology and surgical services, eye and tissue banks, and Organ Procurement Organizations. HTOR's unique systems ensure that tissues procured for customized protocols are delivered in a timely manner to the appropriate research destinations. The quantity, quality and diversity of tissues shipped to investigators is a function of three critical variables: the number and types of sources working with HTOR, the internal systems of HTOR, and the number and types of research requests that HTOR receives from researchers. The specific aims of the proposed funding period focus on strengthening these three arms of the HTOR program (sources, information systems, and researchers). HTOR will work to increase the capabilities of existing sources and add new sources to increase tissue quantity and diversity (Specific Aim 1/Sources); upgrade HTOR's internal systems (computer hardware, software, and data management) to improve data capture and analysis, and upgrade the HTOR Web Site to increase Source and Researcher access to HTOR resources (Specific Aim 2/Systems); and work closely with the research community to fulfill existing and emerging needs for human research tissue (Specific Aim 3/Researchers). In addition, HTOR will continue a specialized program for procuring and distributing HIV positive tissues (Specific Aim 4), a goal that is also consistent with HTOR's long-term objective.