Bone Marrow Stromal Cells as Mitigators of Radiation Injury
Bone Marrow Stromal Cells as Mitigators of Radiation Injury
批准号:
8938111
负责人:
Deborah Citrin
金额:
$45.42万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
AcuteAllogenicAnimalsBone MarrowCellsChronicCutaneousDataDerivation procedureDermatitisEventFibrosisGoalsInflammationInflammatoryInfusion proceduresInjuryLate Radiation InjuryLiteratureLungMarrowModelingMusOutcomeRadiationRadiation InjuriesRadiation ToxicitySiteStromal CellsSystemTissuesWorkclinical applicationcytokineimprovedin vivolung injurymanresponse to injury
中文摘要
到目前为止,我们的研究已经证明骨髓基质细胞是一种有效的辐射损伤缓解剂。我们发现骨髓基质细胞的递送可以减少辐射暴露后的肺和皮肤纤维化。在这些模型中,我们的递送系统显示出肺损伤暴露小鼠的生存延长和皮肤纤维化减少。我们将继续评估骨髓基质细胞是否能减轻放射性皮炎和致死性全身暴露。
英文摘要
Thus far, our studies have documented that bone marrow stromal cells are an effective mitigator of radiation injury. We have found that delivery of bone marrow stromal cells can reduce pulmonary and cutaneous fibrosis after radiation exposure. In these models our delivery system has shown an extension in survival in exposed mice with lung injury and reduction in cutaneous fibrosis. We continue to evaluate if bone marrow stromal cells can mitigate radiation dermatitis and lethal total body exposures.
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Bone Marrow Stromal Cells as Mitigators of Radiation Injury
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批准号:8763514
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项目类别:
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资助金额:$73.19万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Targeting mechanisms of radiation resistance
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批准号:8938188
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项目类别:
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资助金额:$45.42万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Screening to identify protectors and mitigators of Radiation GI Syndrome
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批准号:9556728
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项目类别:
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资助金额:$65.62万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Mechanisms of Normal Tissue Toxicity
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批准号:9153696
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项目类别:
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资助金额:$86.67万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Evaluation of Novel Radiation Modifiers
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批准号:8552862
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项目类别:
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资助金额:$40.66万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Targeting mechanisms of radiation resistance
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批准号:10014725
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项目类别:
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资助金额:$72.42万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Mechanisms of Normal Tissue Toxicity From Irradiation
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批准号:10262171
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项目类别:
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资助金额:$147.42万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Mechanisms of Normal Tissue Toxicity From Irradiation
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批准号:10926083
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项目类别:
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资助金额:$182.99万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Screening to identify protectors and mitigators of Radiation GI Syndrome
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批准号:10486958
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项目类别:
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资助金额:$77.43万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Evaluation of Novel Radiation Modifiers
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批准号:7965759
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项目类别:
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资助金额:$74.23万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Mechanisms of Normal Tissue Toxicity
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批准号:8349205
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项目类别:
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资助金额:$53.72万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Mechanisms of Normal Tissue Toxicity
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批准号:8763251
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项目类别:
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资助金额:$73.19万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Targeting mechanisms of radiation resistance
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批准号:9153977
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项目类别:
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资助金额:$43.33万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Mechanisms of Normal Tissue Toxicity
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批准号:7592997
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项目类别:
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资助金额:$57.76万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Mechanisms of Normal Tissue Toxicity From Irradiation
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批准号:10014468
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项目类别:
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资助金额:$144.83万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Mechanisms of Normal Tissue Toxicity
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批准号:8552863
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项目类别:
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资助金额:$40.66万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Mechanisms of Normal Tissue Toxicity
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批准号:8937873
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项目类别:
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资助金额:$90.84万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Mechanisms of Normal Tissue Toxicity From Irradiation
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批准号:10702425
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项目类别:
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资助金额:$184.66万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Screening to identify protectors and mitigators of Radiation GI Syndrome
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批准号:10262442
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项目类别:
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资助金额:$73.71万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Mechanisms of Normal Tissue Toxicity
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批准号:8157503
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项目类别:
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资助金额:$20.41万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
海外基金