COBRE Center for Cancer Research Development

分子病理学核心 项目总结/摘要 自成立以来，分子病理学核心C的使命一直是提供技术和 为有兴趣了解癌症病理生物学的研究人员提供咨询服务。核还 维持一个肿瘤库（在第一阶段开始），其中包含2064年以来的相邻正常组织和肿瘤组织 患者在我们的COBRE生命周期内，该核心提供的服务提高了生产力， 癌症研究人员的研究能力，并提供了竞争优势， 校外资助这引起并保持了对利用核心服务的极大兴趣， 与罗得岛医院保证的共同资助一起， 第三阶段融资期结束后。核心将努力实现以下具体目标： 目标1. TP继续为罗得岛生物医学中心提供基本的病理检测和服务。 社区目标2.为了维持和扩大我们的肿瘤库的邻近正常和癌组织， 2064名受试者，并继续通过 CCRD网站。目标3：扩展我们的服务，以支持由制造商发起和行业支持的 癌症临床试验，重点是从研究对象中获取和处理组织。目标4：继续 通过参加由菲利普博士领导的第三阶段的试点赠款计划（核心D）来指导初级教师 Gruppuso和Jennifer Sanders为试点/初级研究者支持计划的接受者提供服务 （JISP）由CCRD管理的赠款。目标5：参与教育、知识和管理活动， 通过参加由行政核心（核心A）组织的会议和研讨会，了解COBRE的各个方面。

Molecular Pathology Core Project Summary/Abstract The mission of the Molecular Pathology Core C since its inception has been to provide technical and consultation services to researchers interested in understanding the pathobiology of cancer. The Core also maintains a Tumor Bank (started during Phase I) that contains adjacent normal and tumor tissues from 2064 patients. Services provided by this Core during the life of our COBRE have enhanced the productivity and research capabilities of cancer investigators and have provided a competitive advantage in garnering extramural funding. This has generated and sustained enormous interest in utilization of Core services that together with guaranteed co-funding by Rhode Island Hospital will allow sustainability of the Core during and after the Phase III funding period. The Core will pursue the following specific aims: Aim 1. Tp continue to provide basic pathologic assays and services to the Rhode Island biomedical community. Aim 2. To maintain and expand our tumor bank of adjacent normal and cancerous tissues from 2064 subjects and continue to broadly advertise its existence to the biomedical community at large through the CCRD web site. Aim 3. To expand our services to support both investigator-initiated and industry supported cancer clinical trials focusing on procuring and processing tissue from study subjects. Aim 4: To continue mentoring junior faculty by participating in the Phase III’s Pilot Grants Program (Core D) headed by Drs. Philip Gruppuso and Jennifer Sanders to provide services to recipients of pilot/Junior Investigator Support Program (JISP) grants administered by the CCRD. Aim 5: To participate in the educational, intellectual and managerial aspects of the COBRE by attending meetings and seminars organized by the Administrative Core (Core A).