Imaging Guided Surgery using Fluorescently Labeled Cetuximab

描述（由申请人提供）：来自我们实验室和其他实验室的证据已经证明了荧光标记抗体测量微观疾病以指导手术干预临床前模型的潜力。我们提供了新的数据，证明了荧光标记的抗EGFR抗体在非人灵长类动物中的安全性。我们提出了一项临床试验，荧光标记西妥昔单抗检测亚临床癌症在手术室现有的成像设备，以指导手术切除头颈部癌症。拟议的试验已于2013年9月获得IRB和IND批准。

DESCRIPTION (provided by applicant): Evidence from our lab and others has demonstrated the potential of fluorescently labeled antibodies to measure microscopic disease to guide surgical intervention preclinical models. We present novel data demonstrating safety of the fluorescently labeled anti- EGFR antibody in non-human primates. We propose a clinical trial with fluorescently labeled cetuximab to detect subclinical cancer in the operating room existing imaging equipment to guide surgical resection of head and neck cancer. The proposed trial has received IRB and IND approval in September 2013.