Genetic Risk for Smallpox Vaccine Related to Myocarditis

人口遗传学分析计划的重点是针对人类病原体接种疫苗或由人类病原体感染引起的差异免疫反应的人类遗传变异。我们的目标是复制先前确定的人类基因-表型关联，并阐明与免疫结果相关的已验证遗传变异的功能相关性。研究重点将集中在http://www3.niaid.nih.gov/topics/emerging/list.htm.列出的一种或多种新出现或重新出现的I、II或III类传染病病原体上这些信息将有助于识别个体风险因素，将扩大我们对适用于广泛人类疾病的免疫机制的理解，并将有助于定义风险和免疫的生物标记物，这些生物标记物可能导致新的感染诊断测试或疫苗反应。 这份合同将研究与心肌炎有关的天花疫苗的遗传风险。

The Population Genetics Analysis program is focused on human genetic variation underlying differential immune responses to vaccination against or infection by human pathogens. The goals are to replicate previously identified human genotype-phenotype associations and elucidate the functional relevance of the validated genetic variants that correlate with immune outcome. Research will focus on one or more of the emerging or re-emerging Group I, II, or III infectious agents listed at http://www3.niaid.nih.gov/topics/emerging/list.htm. This information will help to identify individual risk factors, will expand our understanding of immune mechanisms applicable to a broad range of human diseases, and will help define biomarkers of risk and immunity that might lead to novel diagnostic tests of infection or vaccine response. This contract will study the genetic risk for smallpox vaccine related to myocarditis