TAS::75 0903::TAS RECOVERY ACT CONTRACT ACTION - PROVIDING RADIOLOGIC OUTCOMES F

拟议的研究将利用在所有审调处研究参与者中获得的膝部纵向X光片，通过以下方式为审调处公共数据库的用户提供结构终点： 1)采用Kellgren和Lawrence(K-L)分级和个人X线特征评分，综合阅读所有膝关节骨关节炎的患病率、进展和发病情况； 2)定量测量进展组受试者所有膝关节的关节间隙宽度和发病队列受试者患膝骨性关节炎的膝关节间隙宽度。这些评估的结果将通过审调处在线公共网站作为公众使用数据集发布。 正如RFP中指出的那样，OAI队列研究是一个公开的数据库，其中包括4796名患有或有发展为膝骨性关节炎风险的受试者的基线和年度随访评估。OAI的设计目标是 研究骨关节炎发生和发展的影像、生化和遗传生物标志物，以及研究骨关节炎的自然病史和危险因素。OAI的主要关注点是膝盖。标准化膝关节 所有受试者都在基线时进行了膝关节X线片和核磁共振成像，并在所有参加后续临床访问并仍符合膝关节成像条件的受试者中重复进行。为了充分发挥审查处的潜力，拟议的项目将向审查处公共数据库的用户提供一套关于膝关节放射检查的患病率、发病率和病情发展的标准变量 用于膝骨性关节炎的生物标记物(基于MRI的成像、生化和遗传学)、危险因素和自然历史研究的骨关节炎(RKOA)。为了进行这项工作，我们将招募有经验的膝骨性关节炎结构结果阅读中心，并建立记录，为大型流行病学和临床研究提供高质量的数据。审调处已利用这些小组在审调处进展队列中提供有限规模的中央图像评估数据。目前的项目建议在进展亚队列中完成这些中心图像评估，并将这项工作扩展到更大的发病率亚队列。

The proposed study will utilize the longitudinal knee radiographs obtained in all OAI study participants to provide structural endpoints for users of the OAI public databases by: 1) comprehensively reading all of the knee radiographs for OA prevalence, progression and incidence using Kellgren and Lawrence (K-L) grades and individual radiographic feature scores; 2) obtaining quantitative measures of joint space width in all knees of subjects in the Progression cohort and knees with OA in subjects in the Incidence cohort. The results of these assessments will be released as public use datasets through the OAI Online public website. As noted in the RFP, the OAI cohort study is a publicly available database of baseline and annual follow-up assessments in 4,796 subjects who have, or are at risk of developing, knee OA. The OAI was designed for studies of imaging, biochemical and genetic biomarkers of OA incidence and progression, and studies of the natural history and risk factors for OA. The main focus of the OAI is on the knee. Standardized knee radiographs and MRIs of the knee were performed on all subjects at baseline and repeated in all subjects who attended the follow-up clinic visits and who remained eligible for knee imaging. In order to realize the full potential of the OAI, the proposed project will provide users of the OAI public database with a standard set of variables on the prevalence, incidence and progression of radiographic knee OA (RKOA) for use in biomarker (MRI-based imaging, biochemical and genetic), risk factor and natural history studies of knee OA. To perform this work, we will enlist experienced reading centers for knee OA structural outcomes with established track records in providing high quality data for large epidemiological and clinical studies. These teams have already been tapped by the OAI to provide central image assessment data on a limited scale in the OAI Progression cohort. The current project proposes to complete these central image assessments in the Progression subcohort and extend this work to the much larger Incidence subcohort.