Coordinating Center to Help Eliminate/Reduce Oral health Inequalities in Children

 描述(由申请人提供)：拟建的“帮助消除/减少儿童口腔健康不平等协调中心”(CC HERERICIC；简称CC)将为8个由UH2/UH3 NIDCR资助的两阶段社区参与项目(RFA-DE-15-006)提供合作研究和协调中心的专业知识和服务，以评估多层次干预措施、计划或政策，以减少或消除不同、易受伤害的0至21岁儿童群体的口腔健康差异。UH2/UH3项目PD/PIS、NIDCR和CC将组成一个合作研究联盟。这8个项目将与多学科小组一起处理一系列多层次的行动机制。拟议的CC调查员和工作人员团队拥有口腔健康、社会和行为科学、微生物学、遗传学、流行病学、卫生政策、卫生经济学和生物统计学方面的相关跨学科专业知识，以及在NIH研究联盟内为多个健康和口腔健康项目服务的数据协调中心的经验。作为NIDCR早期儿童龋病协作中心数据协调中心(NIDCR EC4 DCC)，该团队已经展示了其协作和创造性地支持大规模、临床相关和社区参与的口腔健康差异研究的能力，同时在6个UH2类研究中，然后在6个机构跨3个时区的4个UH3类随机临床试验中，以满足总体科学和 项目社区合作伙伴目标。我们将利用NHLBI数据协调中心最佳实践简编以及社区-校园卫生伙伴关系关于可信伙伴关系的立场声明。CC将与每个UH2/UH3项目建立持续的合作关系，以提供以下领域的服务和专业知识：(A)与口腔健康相关的临床知识；(B)定性和定量研究设计 (C)选择、开发和完善测量仪器，包括统一8个UH2/UH3项目的测量方法；(E)信息学，包括提供安全、定制的数据采集系统以及项目和临床研究管理系统；(F)使用这些系统的培训；(G)参与者安全监测和向项目调查员、临床业务承包商和独立的数据和安全监测委员会报告；(H)数据管理、处理和质量控制；(I)制定定性和定量数据分析计划；(J)向项目调查员、NIDCR和数据和安全监测委员会报告项目进展情况；以及(K)协调和参加财团会议，包括定期指导委员会、特设合作工作组和外部科学咨询委员会(ESAC)年度会议。我们经验丰富的儿童口腔健康协调中心团队可以为这些UH2/UH3项目提供高效、全面的支持，确保科学严谨，满足社区需求。

 DESCRIPTION (provided by applicant): The proposed "Coordinating Center to Help Eliminate/Reduce Oral health Inequalities in Children" (CC HEROIC; CC for short) will provide collaborative research and coordinating center expertise and services to 8 two-phase UH2/UH3 NIDCR-funded community-engaged projects (RFA-DE-15-006) to assess multilevel interventions, programs or policies to reduce or eliminate oral health disparities in diverse, vulnerable populations of children aged 0 to 21 years. The UH2/UH3 project PD/PIs, the NIDCR, and the CC will form a collaborative research consortium. The 8 projects will address a range of multilevel mechanisms of action with multidisciplinary teams. The proposed CC investigator and staff team possesses relevant transdisciplinary expertise in oral health, social and behavioral sciences, microbiology, genetics, epidemiology, health policy, health economics, and biostatistics, plus data coordinating center experience serving multiple health and oral health projects within NIH research consortia. As the NIDCR Early Child Caries Collaborating Centers Data Coordinating Center (NIDCR EC4 DCC) the team has demonstrated its ability to collaboratively and creatively support large-scale, clinically-relevant, and community-engaged oral health disparities research simultaneously in 6 UH2-like studies and then in 4 UH3-like randomized clinical trials in 6 institutions across 3 time zones to meet the overall scientific and project community partner goals. We will utilize both the NHLBI Compendium of Best Practices for Data Coordinating Centers as well as the Community-Campus Partnership in Health's Position Statement on Authentic Partnerships. The CC will establish ongoing, collaborative relationships with each UH2/UH3 project to provide services and expertise in the following areas: (a) oral health-related clinical knowledge; (b) qualitative and quantitative research design with particular emphasis on oral health outcomes in diverse, community-based, pediatric populations; (c) selecting cost measures and designing cost analyses; (d) selecting, developing, and refining measurement instruments, including harmonizing measures across the 8 UH2/UH3 projects; (e) informatics, including providing secure, customized data acquisition systems and project and clinical research management systems; (f) training in the use of those systems; (g) participant safety monitoring and reporting to the project investigators, NIDCR, the clinical operations contractor, and an independent Data and Safety Monitoring Board (DMSB); (h) data management, processing, and quality control; (i) developing qualitative and quantitative data analysis plans; (j) reporting on project progress to the project investigators, NIDCR, and the Data and Safety Monitoring Board; and (k) coordinate and participate in consortium meetings including regular Steering Committee, ad hoc Collaborating Working Group, and annual External Scientific Advisory Committee (ESAC) meetings. Our experienced children's oral health coordinating center team can provide efficient, comprehensive support to these UH2/UH3 projects to assure scientific rigor and meet community needs.