Adolescents with Substance and Conduct Problems: Imaging Callous-Unemotionality

描述（由申请人提供）：本提案由一名早期研究者提交，寻求四年的R01支持，对有严重物质和行为问题的青少年患者和青少年对照进行MRI研究。本研究旨在确定冷酷无情（CU）的神经关联（功能和结构）。CU在儿童和青少年时期是可识别的，成年后是一个相对稳定的特征，与持续的反社会行为问题和物质依赖有关；患有CU、反社会行为问题和物质使用障碍的个体似乎对治疗更有抵抗力。这一建议也将允许寻找青少年发病物质依赖亚型的神经相关性。我们将招募，完成广泛的诊断性访谈，并在受试者玩艾伦的游戏时给他们拍照。该游戏是为在MRI环境中使用而设计的，在我们的无磁先导测试中显示出与CU特征分数的强烈关系。

DESCRIPTION (provided by applicant): This proposal, submitted by an early stage investigator, seeks four years of R01 support to conduct an MRI study of adolescent patients with serious substance and conduct problems and adolescent controls. This proposal seeks to identify the neural correlates (both functional and structural) of callous-unemotionality (CU). CU is identifiable in childhood and adolescence, is a relatively stable trait into adulthood, and is linked with persistent antisocial behavior problems and substance dependence; individuals with CU, antisocial behavior problems and substance use disorders appear more resistant to treatment. This proposal will also allow searching for neural correlates of subtypes of adolescent-onset substance dependence. We will recruit, complete extensive diagnostic interviews and image subjects while they play the AlAn's game. That game, which was designed for use in the MRI environment, has demonstrated a strong relationship with CU trait scores in our out-of-magnet pilot testing.