Core A: Biostatistics and Bioinformatics Core

项目摘要-核心A 生物统计学和生物信息学核心的目的是提供一个全面的、多学科的 生物统计学和生物信息学方面的专业知识资源。核心A的成员将与 来自每个项目的研究人员将他们的假设转化为可检验的统计假设并发表讲话 相应的调查对象是各级。这包括设计基础实验和动物实验， 管理和维护所产生的数据、数据分析以及统计和生物信息学推断，以及 根据从探索和可视化中产生的发现，形成新的假设 数据。核心A是研究人员可以从中汲取统计和生物信息学专业知识的焦点 用于规划、管理和分析他们的学习。它还开发、测试和实现了各种 适用于癌症研究的统计分析技术，包括数学建模。类型 支持的研究包括基础科学和翻译研究。即将发布的大量信息 在拟议的研究项目和核心中产生的数据需要计算机工具来协调 努力和数据管理。核心A的主要作用将是提供最先进的生物统计 以及生物信息学方法和软件流水线，用于高效的数据分析和建立集中化的 关系数据库系统和数据管理结构，便于输入、存储和检索所有 由计划项目生成的数据，并允许在多个 项目和核心。与该计划相关的所有调查人员都可以使用未识别的信息 项目。由于此核心存储的信息的敏感性质，我们将采取广泛的预防措施 保护参与者的机密性。所有IRB和HIPAA的规定将得到严格执行。通过提供 向调查人员提供数据访问，共享技术能力，并确保数据、数据的质量 这一核心的管理部分将促进项目目标的实现并鼓励探索性 超出所述范围的分析。

Project Summary - Core A The purpose of the Biostatistics and Bioinformatics Core is to provide a comprehensive, multi-disciplinary resource of expertise in biostatistics and bioinformatics. Members of Core A will collaborate closely with investigators from each project in translating their hypotheses into testable statistical hypotheses and address the corresponding aims at all levels of investigation. This consists of designing basic and animal experiments, managing and maintaining the resulting data, data analysis and statistical and bioinformatics inference, and formulating new hypotheses based on discoveries arising from exploration and visualization of the integrated data. Core A serves as a focal point from which investigators may draw statistical and bioinformatics expertise for planning, management and analysis of their studies. It also develops, tests and implements various techniques of statistical analysis, including mathematical modeling, applicable to cancer research. Types of research supported include basic science and translational studies. The large volume of information to be generated in the proposed research projects and cores requires computer-based tools for the coordination of efforts and the management of data. The primary role of Core A will be to provide state-of-art biostatistics and bioinformatics methods and software pipelines for efficient data analysis and establish a centralized relational database system and data management structure that facilitates the entry, storage and retrieval of all data generated by the program project, and permits the controlled exchange of information across the several projects and cores. De-identified information will be available to all investigators associated with this program project. Due to the sensitive nature of the information stored by this Core, we will take extensive precautions to protect the confidentiality of participants. All IRB and HIPAA regulations will be strictly enforced. By providing data access to investigators, sharing technical capabilities, and ensuring the quality of the data, the data management component of this core will facilitate achievement of the project aims and encourage exploratory analyses beyond those stated.