Predoctoral Training in Genetics and Development

描述(由申请者提供)：我们寻求支持，以继续我们在康奈尔大学的遗传学和发育(G&D)研究生培训计划。遗传学是研究遗传、突变、基因组组织、疾病外显性、基因调控、种群结构和进化机制的一种基本和令人兴奋的方法。这种方法提供了强大的分析工具，可以应用于发育生物学，这是我们的第二个重点。过去的五年对G&D培训师来说尤其富有成效。我们培训人员的论文包括高影响力的基因组和数量性状分析，以及大量优雅的遗传和发育遗传学研究。我们的培训人员正在将在基本模型系统中获得的成果与人类健康和疾病联系起来，包括糖尿病、癌症综合征、生育和代谢综合征，并正在使用再生疗法和人类发展的模型。此外，G&D培训师实验室的学生平均每个完成的博士学位有3.8篇论文，他们在理解罕见的等位基因如何导致人类疾病方面取得了重大进展，并正在解决导致人类疾病的遗传交互作用。我们的项目被普遍认为有别于校园内的其他研究生培训项目和培训助学金，它开发了一套强大的课程，为校园内的学生和教职员工提供服务。G&D培训师精力充沛，资金充足(每个培训师每年的直接成本为358,800美元)，高度协作，是康奈尔大学生命科学四个关键中心的负责人。我们继续吸引优秀的研究生(在竞争激烈的环境下，高质量学生的录取率为44%)，并加大了努力，并保持了在招收少数族裔学生方面的成功。我们继续评估我们的课程，目前正在微调数量生物学和伦理问题与责任方面的课程。我们不断地征求学生对我们项目各个方面的反馈意见。我们的学生毕业后受雇于遗传学和发展领域，并通过课程作业和指导利用职业建议。在接下来的五年里，随着即将退休的康奈尔大学生命科学部门的招聘，以及威尔细胞和分子生物学研究所新的遗传学家的加入，我们预计该领域活跃的年轻培训师将继续增长。这笔培训赠款提供的资金和方案支持对我们项目的发展和成功至关重要。只有在持续的支持下，我们才能继续和提高我们培养一流科学家的记录。

DESCRIPTION (provided by applicant): We seek support to continue our program of graduate student training in Genetics and Development (G&D) at Cornell University. Genetics is a fundamental and exciting approach to study the mechanisms that underlie inheritance, mutation, genome organization, disease penetrance, gene regulation, population structure, and evolution. This approach provides powerful analytical tools that can be applied to Developmental Biology, our second emphasis. The last five years has been especially productive for G&D Trainers. Papers from our Trainers include high-impact genomic and quantitative trait analyses in addition to a large number of elegant genetic and developmental genetic studies. Our Trainers are connecting results obtained in basic model systems to human health and disease, including diabetes, cancer syndromes, fertility and metabolic syndromes, and are using models for regenerative therapies and human development. In addition, students in G&D Trainer labs, averaging 3.8 papers per completed Ph.D., are making significant headway in understanding how rare alleles can contribute to disease in the human population and are tackling genetic interactions that underlie human disease. Our program, universally viewed as being distinct from other graduate training programs and training grants on campus, has developed a strong curriculum that serves students and faculty across campus. G&D Trainers are energetic, well-funded ($358,800 in annual direct costs/trainer), and highly collaborative, and are leaders of four critical centers in the Life Sciences at Cornell. We continue to attract outstanding graduate students (44% acceptance rate of high quality students in a very competitive environment) and have increased our efforts and maintained our success at recruiting minority students. We continue to evaluate our curriculum and are currently fine tuning coursework in quantitative biology and ethical issues and responsibilities. We constantly ask for feedback from our students on all aspects of our program. Our students are being employed in genetics and development fields after graduation and are taking advantage of career advice through coursework and mentoring. Over the next five years with hiring in the life sciences at Cornell resulting from impending retirements and the addition of new geneticists in the Weill Institute of Cell and Molecular Biology, we anticipate continued growth of active young trainers in the Field. The financial and programmatic support provided by this training grant has been crucial to the growth and success of our program. Only with continued support will we be able to continue and improve our record of training first- rate scientists.