Overall: The University of Rochester Resource-Based Center for Musculoskeletal Biology and Medicine

 描述（申请人提供）：这是一个建立罗切斯特大学肌肉骨骼生物学和医学资源中心的建议（URRBCMBM），由一个管理核心组成，该管理核心将运行富集计划，并协调和整合组织学、生物化学和分子成像（HBMI）以及生物力学，生物材料和多模态组织成像（BBMTI）核心，以确保整体URRBCMBM的有效进展。行政核心的内部和外部咨询委员会和会议结构是URRBCMBM研究人员以及与肌肉骨骼研究中心和大学内合作部门和中心的其他教师之间的沟通和合作组织的关键要素。URRBCMBM的具体目标是：1）为基础科学、转化和临床肌肉骨骼研究保持最先进的基于资源的核心;并以具有成本效益的方式利用这些资源，加快发现和临床转化的步伐。2)继续促进我们的高度协作环境，作为一个互动的资源为基础的中心内的基础研究转化为临床试验的模式，并扩大我们的推广活动，促进核心提供的资源的使用，以新的外部合作，这将使我们的肌肉骨骼研究基地在URMC，国内和国际。3)为了将我们的试点赠款计划从每年10万美元增加到20万美元，机构资金和慈善事业将针对NIH标准定义的新研究者，并在这些试点赠款之外加强我们的富集计划，William F.纽曼客座教授系列，和年度肌肉骨骼研究研讨会，通过积极扩大研究社区和促进肌肉骨骼生物学和医学的创新研究。4)维持我们的CTSC，与CTSI一起管理人类受试者研究服务，加强基础科学向临床应用的转化，并发展合作网络，新的重点是大数据科学和人口健康研究。和5）扩大我们非常成功的指导计划，这有助于我们的新研究人员晋升为NIH R 01资助的PI和国家领导地位，并实施最高标准的科学严谨性，以响应NIH的计划，以提高可重复性。

 DESCRIPTION (provided by applicant): This is a proposal to establish the University of Rochester Resource-Based Center for Musculoskeletal Biology and Medicine (URRBCMBM), which is comprised of an Administrative Core that will run the Enrichment Program, and coordinate and integrate the Histology, Biochemistry and Molecular Imaging (HBMI) and the Biomechanics, Biomaterials and Multimodal Tissue Imaging (BBMTI) Cores to ensure progress of the overall URRBCMBM in an efficient manner. The Internal and External Advisory Committees and meeting structure of the Administrative Core are key elements of organization of communication and collaboration among the URRBCMBM investigators as well as with other faculty in the Center for Musculoskeletal Research and collaborating Departments and Centers within the University. The Specific Aims of the URRBCMBM are: 1) To maintain state-of-the-art resource-based Cores for basic science, translational and clinical musculoskeletal research; and utilize these resources in a cost-effective manner to accelerate the pace of discovery and clinical translation. 2) To continue to foster our highly collaborative environment that serves as model for translation of basic research to clinical trials within an interacting Resource-Based Center, and expand our outreach activities that promote the use of the resources offered by the Core to new external collaborations that will grow our musculoskeletal research base at URMC, nationally and internationally. 3) To grow our Pilot Grant Program from $100,000 to $200,000 per year with institutional funds and philanthropy, which will be targeted to New Investigators as defined by NIH criteria, and enhance our Enrichment Programs beyond these Pilot Grants, the William F. Newman Visiting Professor series, and Annual Musculoskeletal Research Symposium, by actively expanding the research community and promoting innovative research in musculoskeletal biology and medicine. 4) To maintain our CTSC that administers human subject research services in concert with the CTSI, to enhance the translation of basic science to clinical application, and grow collaborative networks with a new emphasis on Big Data science and population health research. And 5) To expand our highly successful Mentoring Program, which facilitates the advancement of our New Investigators to NIH R01 funded PI and national leadership status, and implements the highest standards of scientific rigor in response to NIH's plan to enhance reproducibility.