Intellectual and Developmental Disabilities Research Centers 2013

此修订后的申请继续支持智力和发育障碍研究 中心（IDDRC）在肯尼迪克里格研究所和约翰霍普金斯大学提交的回应， RFA-HD-14-012。IDDRC将继续支持一个大型，多样化和多学科的计划， 研究重点是发展障碍，重点是转化研究，作为 在一个首屈一指的教育，临床和 生物医学研究机构。IDDRC将包括六个核心。行政核心（A） 将为中心提供领导，管理和组织支持;协调教育 计划组成部分（讲座和研讨会）;代表中心与研究所的互动， 大学行政部门;并作为与NICHD、其他IDDRCs和 更广泛的社区。临床翻译核心（B）将支持中心研究者开展以下相关活动 参与者招募、IRB相关活动、生物统计学和沿着整个翻译过程移动发现 通路遗传学核心（C）将提供集中的组织培养和细胞遗传学援助， 专业分子遗传学、微阵列和测序研究以及生物信息学。平移 神经科学核心（D）将提供组织学和临床前成像设施，以及一组高度 针对与发育障碍相关的代谢物和分子的专门测定。一 神经影像核心（E）将为研究者提供获取和定量分析方面的帮助 从功能、体积、扩散张量和光谱MR成像获得的数据，以及 采用TMS方法的研究。最后，行为科学核心（F）将为参与者提供培训， 与研究方案合作，选择神经心理学/认知评估方法， 功能磁共振成像激活模式的设计，以及运动功能评估的专门方法。核心 今年将向69个项目提供支持，这些项目每年的联邦资金超过34美元。 100万美元，加上由中心直接资助的研究部分。

This revised application for continued support of the Intellectual and Developmental Disabilities Research Center (IDDRC) at the Kennedy Krieger Institute and Johns Hopkins University is submitted in response to RFA-HD-14-012. The IDDRC will continue supporting a large, diverse and multidisciplinary program of research focused on developmental disorders with an emphasis on translational research, serving as the nexus for research focused on developmental disabilities within one of the premiere educational, clinical, and biomedical research institutions in the world. The IDDRC will include six Cores. An Administrative Core (A) will provide leadership, management, and organizational support for the Center; coordinate educational program components (lectures and seminars); represent the Center In Interactions with Institute and University administration; and serve as the interface with colleagues at NICHD, other IDDRCs, and the broader community. A Clinical Translational Core (B) will support Center investigators in activities related to participant recruitment, IRB-related activities, biostatistics and moving findings along the entire translational pathway. A Genetics Core (C) will provide centralized tissue culture and assistance with cytogenetics, specialized molecular genetics, microarray and sequencing studies, and bioinformatics. A Translational Neuroscience Core (D) will provide histology and preclinical imaging facilities, as well as a group of highly specialized assays that target metabolites and molecules of relevance to developmental disorders. A Neuroimaging Core (E) will provide Investigators with assistance in acquisition and quantitative analysis of data derived from functional, volumetric, diffusion tensor, and spectroscopic MR imaging, as well as for studies employing TMS methods. Finally, a Behavior Science Core (F) will offer training of participants for cooperation with research protocols, selection of methods for neuropsychological/cognitive assessment, design of activation paradigms for fMRI, and specialized methods for assessment of motor functioning. Core support this coming year will be provided to 69 projects representing annual federal funding of over $34 million, plus a Research Component funded directly by the Center.