2017 Salivary Glands and Exocrine Biology Gordon Research Conference & Gordon Research Seminar

项目摘要 该提案要求部分支持第十一届戈登研究会议（GRC）和第一届 戈登研究研讨会（GRS）的“唾液腺和外分泌生物学”题为“了解 分泌组织的发育、功能和再生： 治疗外分泌失调”将于2017年2月18日至24日在德克萨斯州加尔维斯顿的加尔维斯顿酒店举行。 GRC将包括关于外分泌腺发育，再生方法， 唾液蛋白的功能相关性，外分泌腺的膜功能，了解 自身免疫性疾病的病因学，靶向炎症以延缓疾病发病机制和当前主题 外分泌腺的细胞生物学。GRC的特邀演讲者将包括来自以下国家的杰出科学家： 学术界，工业界和政府，会谈将包括来自不同领域的高级和初级科学家 将在前一次会议确定的主题上提交当前未发表的研究结果的领域 组织者和与会者作为最感兴趣的领域。将邀请多位主讲人， 提供关于干燥综合征的干细胞治疗、临床基因组学和临床试验的研讨会， 常见的自身免疫性疾病，影响外分泌腺和负面影响的生活质量， 没有合适和有效的治疗方法的患者。本届GRC的一项创新将是 第一次包括在GRC之前举行的GRS，仅邀请以下发言者： 研究生和博士后助理在世界各地的各种实验室。这些小型 科学家在地球科学研究所也将参加地球科学研究中心，其中许多人将被选为给研讨会， 将列入全体会议。此外，集选区亦会每天举行海报展览， 使所有与会者能够在一个开放的论坛中展示和讨论他们的数据。GRC的总体目标和 GRS将促进科学交流，并在以下学科中开展研究合作： 被视为对发展改善人类健康的新战略具有重大影响。 符合NIDCR使命的具体目标包括：1）提出一个专题感兴趣的方案， 学术界、工业界和政府的科学家，并将初级和高级研究人员聚集在一个 愉快的环境，他们将有机会提出未发表的发现之前， 知识渊博的观众，并从事广泛的关键研究讨论; 2）提供 第一次，GRS将由研究生和博士后同事参加，他们将展示他们的 新颖的研究成果面前的观众，他们的同龄人和; 3）强调介绍国家的， 外分泌生物学领域感兴趣的最先进的方法论， 通过预防分泌器官紊乱来改善人类健康的方法。

Project Summary This proposal requests partial support for the Eleventh Gordon Research Conference (GRC) and the first Gordon Research Seminar (GRS) on “Salivary Glands and Exocrine Biology” entitled “Understanding development, function and regeneration of secretory tissues: novel signaling pathways and approaches to treat exocrine disorders” to be held from February 18-24, 2017 at the Hotel Galvez in Galveston, Texas. The GRC will include plenary sessions on exocrine gland development, regenerative approaches, functional relevance of salivary proteins, membrane functions in exocrine glands, understanding the etiology of autoimmune disease, targeting inflammation to retard disease pathogenesis and current topics in cell biology of exocrine glands. Invited speakers for the GRC will include eminent scientists from academia, industry and government and talks will include both senior and junior scientists from diverse fields who will present current unpublished research findings on subjects identified by previous meeting organizers and attendees as of greatest interest to the field. Several keynote speakers will be invited to deliver seminars on stem cell therapeutics, clinical genomics and clinical trials for Sjögren’s syndrome, a common autoimmune disease that affects exocrine glands and negatively impacts the quality of life of patients for whom no suitable and effective therapies are available. An innovation at this GRC will be inclusion for the first time of a GRS to be held just prior to the GRC that will invite only speakers who are graduate students and postdoctoral associates in a wide variety of laboratories worldwide. These junior scientists at the GRS will also attend the GRC where many of them will be chosen to give seminars that will be included in the plenary sessions. In addition, poster sessions will be held daily at the GRC to enable all attendees to present and discuss their data in an open forum. The overall goal of the GRC and GRS will be to foster scientific exchanges and engender research collaborations in disciplines that are viewed as having a major impact on the development of novel strategies to improve human health. Specific Aims in line with the NIDCR mission include: 1) to present a program of topical interest to scientists in academia, industry and government and to assemble junior and senior investigators in a pleasant setting where they will have opportunities to present unpublished findings before a knowledgeable audience and engage in a wide range of critical research discussions; 2) to offer for the first time, a GRS to be attended by graduate students and postdoctoral associates who will present their novel research findings before an audience of their peers and; 3) to emphasize presentations on state-of- the-art methodologies of interest to the exocrine biology field towards the goal of developing innovative approaches to the improvement of human health by preventing disorders of secretory organs.