Malaria Transporters as a novel target for Antimalarial Campaign

项目亮点：使用小型化至1536孔板格式的8种不同培养基，筛选MMV盒、NPC和NCGC MIPE文库的集合。正在对阳性化合物进行进一步的化合物选择测试。 在此期间，NCGC促进并保持了与NIH和校外研究人员的180多项积极合作，促进了整个人类疾病谱的药物发现工作。 这些努力已经导致了100多个高通量筛选和近60个药物化学活动，为我们的合作者和一般研究社区提供了丰富的出版物和有前途的小分子线索。 此外，NCGC还承担了一系列信息挑战，以更好地利用现有的药物和疾病靶点信息，并为公众提供易于获取的资源，进一步促进人类疾病新疗法的开发。

Project highlights: using miniaturized to 1536-well plate format with 8 different media, collections of MMV box, NPC and NCGC MIPE libraries were screened. The positive compounds are being tested for further compound selections. During this period, the NCGC has fostered and maintained over 180 active collaborations with both NIH and extramural investigators, facilitating drug discovery efforts across the entire spectrum of human disease. These efforts have led to over 100 high-throughput screens and nearly 60 medicinal chemistry campaigns, providing our collaborators and the general research community a wealth of publications and promising small molecule leads. In addition, the NCGC has undertaken a number of informatic challenges to make better use of existing drug and disease target information and provide the general public with easily accessible resources, further catalyzing the development of new therapies for human disease.