Protein Structure and Function

蛋白质构成活细胞的大部分功能成分和许多结构成分。因此，他们 对人类健康和疾病都至关重要。在过去的十年里，科布雷-PSF一直在追求 蛋白质结构和功能方面与健康相关的基础研究。在这样做的同时，我们帮助招募了25名新的 堪萨斯大学和我们的三个合作机构(堪萨斯州立大学)的生物医学研究人员 大学、威奇托州立大学和密歇根大学医学院)。我们还建造了三个非常成功的 科学核心实验室致力于a)蛋白质生产，b)蛋白质X射线结晶学，以及c)生物分子 核磁共振波谱。因此，Cobre-PSF在加强人体和身体方面做了很多工作 堪萨斯州生物医学研究的资源。这项申请要求五年的资金用于 Cobre-PSF的第三阶段，在此期间，我们将追求以下目标：1)我们将继续发展 大量新的和继续的研究人员专注于蛋白质结构和蛋白质的非常广泛的主题 功能；2)我们将继续利用我们的核心实验室成功地实施Cobre试点项目赠款计划； 3)我们将通过扩展现有核心实验室的功能和用户基础，并通过 与科罗拉多大学研究中心合作，根据 所产生的费用加上来自大学的支持基数。这样做的结果将是非常 职业生涯中期成功的生物医学研究人员的强大干部和自给自足的核心实验室团队 支持全州范围内的蛋白质结构和功能研究。科布雷-PSF的总体影响将 因此，这将是实质性的和持久的。

Proteins comprise most of the functional and many of the structural components of living cells. Hence, they are vitally important to both human health and disease. For the past ten years COBRE-PSF has pursued basic health-related research in protein structure and function. While doing so we helped to recruit 25 new biomedical research faculty to The University of Kansas and our three partner institutions (Kansas State University, Wichita State University and the KU School of Medicine). We also built three highly successful scientific Core Labs dedicated to a) protein production, b) protein X-ray crystallography, and c) biomolecular NMR spectroscopy. As a result COBRE-PSF has done much to strengthen both the human and the physical resources for biomedical research in the state of Kansas. This application requests five years of funding for Phase III of COBRE-PSF, during which time we will pursue the following aims: 1) we will continue growing a critical mass of new and continuing investigators focused on the very broad theme of protein structure and function; 2) we will continue a successful program of COBRE pilot project grants that utilize our Core Labs; 3) we will strengthen our existing Core Labs by expanding their capabilities and their user base and by working with the KU Center For Research to position them for long-term sustainability based on a combination of fees generated plus a base of support from the University. The result of this will be a very strong cadre of successful mid-career biomedical research faculty and a self-sustaining group of Core Labs that support research in protein structure and function statewide. The overall impact of COBRE-PSF will thus be substantial and long-lasting.