Health related quality of life and seizure medications after hemorrhagic stroke

 描述（由申请人提供）：此应用程序响应AHRQ K18（以患者为中心的结果研究，PCOR指导职业提升奖）为职业生涯中期的研究人员。Andrew M Naidech，MD MSPH在神经血管和卒中结局研究方面拥有专业知识，并打算在PCOR过渡到独立的职业生涯。该提案包括变革和组织振兴方案的正规教育和比较有效性研究，以补充其生物统计学培训，并利用AHRQ资助的K12 NU-患者方案。候选人Naidech博士是一名血管神经科医生和神经重症监护医师，接受过正式的生物统计学培训，并在出血性卒中（拟定的研究主题）中进行了基于结局的临床研究。他创立了西北大学脑梗死登记处（NUBAR），该登记处已招募了近400名ICH患者。自2009年以来，NUBAR的数据已经超过40篇出版物，证明了持续的生产力。自2011年以来，Naidech博士将生活质量结果纳入NUBAR，为比较有效性研究创建了丰富的数据集。教育主要导师是Jane Holl（医学博士、公共卫生硕士），她是AHRQ支持的著名研究员兼西北大学健康科学教育中心主任。PCOR导师是大卫切拉博士，NU-PATIENT教育项目、NIH患者报告结局测量信息系统（PROMIS）统计中心和Neuro-QOL的PI。比较有效性研究导师是拉里·赫奇斯博士，西北大学政策研究所所长和生物统计学主席。环境西北大学是变革和组织振兴方案的国家领导者。PROMIS和Neuro-QOL在切拉博士的领导下在NIH的资助下在西北大学部分开发。自2011年以来，已采集了入组NUBAR的患者的PROMIS和神经-QOL结局。新推出的芝加哥地区以患者为中心的结局研究网络（CAPriCORN，PCARI临床数据研究网络）检索了多个地区医疗保健组织关于再住院、药物治疗的数据，并将为本提案提供多中心数据。Research.这种为期两年的密集体验利用了NUBAR和CAPriCORN收集的现有数据。在本提案中，我们将检查预防性癫痫发作药物对NUBAR和CAPriCORN再住院的影响，以及使用最先进的PROMIS和Neuro-QOL方法获得的NUBAR入组患者的健康相关生活质量数据。这项研究和培训将导致未来与以患者为中心的结果研究所（PCRI），AHRQ和NIH的独立性，利用比较有效性的研究方法，以改善以患者为中心的结果。

 DESCRIPTION (provided by applicant): This application responds to the AHRQ K18 (Mentored Career Enhancement Award in Patient Centered Outcomes Research, PCOR) for mid-career investigators. Andrew M Naidech, MD MSPH has a track record of expertise in neurovascular and stroke outcomes research and intends to transition to an independent career in PCOR. The proposal includes formal education in PCOR and comparative effectiveness research that complements his biostatistics training, and utilizes the AHRQ-funded K12 NU- PATIENT program. Candidate. Dr. Naidech is a vascular neurologist and neurointensivist with formal biostatistics training and a track record of outcomes-based clinical research in hemorrhagic stroke, the proposed topic of study. He founded the Northwestern University Brain Attack Registry (NUBAR), which has enrolled nearly 400 patients with ICH. NUBAR data have had to >40 publications since 2009, attesting to continued productivity. Dr. Naidech has enfolded quality of life outcomes into NUBAR since 2011, creating a rich dataset for comparative effectiveness research. Education. The primary mentor is Jane Holl, MD, MPH, a noted AHRQ-supported researcher and Director of the Center for Education in Health Sciences at Northwestern. The PCOR mentor is David Cella, PhD, PI of the NU-PATIENT educational program, the NIH Patient Reported Outcomes Measurement Information System (PROMIS) Statistical Center, and Neuro-QOL. The comparative effectiveness research mentor is Larry Hedges, PhD, Director of the Institute for Policy Research and Chair of Biostatistics at Northwestern. Environment. Northwestern is a national leader in PCOR. PROMIS and Neuro-QOL were partially developed at Northwestern under Dr. Cella's leadership with NIH funding. PROMIS and Neuro-QOL outcomes have been captured for patients enrolled in NUBAR since 2011. The newly available Chicago Area Patient Centered Outcomes Research Network (CAPriCORN, a PCORI Clinical Data Research Network) retrieves data from multiple area healthcare organization on rehospitalization, medications, and will provide multi-center data for this proposal. Research. This two-year intensive experience takes advantage of existing data collected by NUBAR and CAPriCORN. In this proposal we will examine the impact of prophylactic seizure medications on rehospitalization from both NUBAR and CAPriCORN, and health-related quality of life data obtained with state- of-the-art PROMIS and Neuro-QOL methods for patients enrolled in NUBAR. This research and training will lead to future independence with the Patient Centered Outcomes Research Institute (PCORI), AHRQ and NIH utilizing comparative effectiveness research methods to improve patient-centered outcomes.