Core B: Repository Core

核心B：存储库核心 项目总结/摘要 为了促进利用创新的分子、细胞和动物模型系统来检查 mHTT和TRiC网络之间的相互作用，并检查TRiC试剂调节对 高清病理，我们将建立一个知识库的核心。存储库是多研究人员的关键资源 发起了研究，并已建立了国家卫生研究院计划检查神经退行性疾病， 紊乱通常，储存库存储和编目各种试剂、方案和其他关键数据， 总体意图旨在迅速促进资源共享，以开发新疗法。 为所述建议书中的工作建立一个知识库核心是计划项目资助的重要组成部分 支持项目目标。知识库核心将通过促进整个项目的研究， 生产标准化的高质量肽、载体、细胞和组织试剂，试剂存档， 协议和分发到项目现场。具体目标是：1）建立一个物理核心， TRiC和HTT试剂和一个程序专用网络，2）协调核心的使用

CORE B: REPOSITORY CORE PROJECT SUMMARY/ABSTRACT In order to facilitate the goal of utilizing innovative molecular, cellular and animal model systems to examine the interactions between mHTT and the TRiC network and to examine TRiC reagent modulations impact on HD pathology, we will establish a repository core. Repositories are a critical resource for multi-researcher initiated studies and have been established for NIH programs examining neurodegenerative diseases and disorders. In general, repositories store and catalogue various reagents, protocols and other critical data with the overall intention aimed at rapidly facilitating sharing resources for the development of new therapies. Establishing a repository core for the work in the described proposal is a vital part of the Program Project Grant to support the project goals. The Repository Core will support research throughout the projects by facilitating production of standardized high quality peptide, vector, cell and tissue reagents, archiving of reagents and protocols and distribution to project sites. Specific aims are to; 1) Establish a physical core for deposition of TRiC and HTT reagents and a Program specific network, 2) Coordinate utilization of the Core