Genetic and Environmental Origins of the Development of Pain in Children

项目描述 拟议的跨学科研究项目是第一个弥合理论和方法差距的项目 儿科健康心理学和行为遗传学之间的联系，以显著提高我们对 孩子的痛苦。对儿童疼痛的研究表明， 环境因素是儿童慢性疼痛的发展和维持的基础。关键 在预防和干预努力产生最大影响之前，需要解决这些问题。的 四个目标解决了疼痛研究领域的四个关键问题：1）遗传和环境病因学 疼痛，2）疼痛的代际传播，3）环境风险和保护因素在其中的作用 疼痛，并在调节疼痛的遗传性，和4）疼痛的增长，包括双向关系， 疼痛和一般失调之间的联系慢性疼痛通常与情绪共病 我们检查疼痛和情绪，行为和生理失调的程度， 有共同的病因为了实现我们的目标，我们建议进行纵向随访（9，10和11）。 11岁）的出生记录为基础的社区样本的350对不同种族的双胞胎儿童。 环境的早期风险和复原力方面已经得到很好的描述，包括产科 从医疗记录中编码的并发症和新生儿发病率，以及早期养育。多元方法 方法包括对双胞胎儿童的疼痛频率、强度、持续时间和残疾进行客观评估 还有他们的父母结合这些设计特征， 通过阐明将支持预防性干预努力的程序作出贡献。

Project Description The proposed interdisciplinary research project is the first to bridge the theoretical and methodological gaps between pediatric health psychology and behavior genetics to significantly advance our understanding of children's pain. The body of research examining childhood pain points to the likelihood that multiple genetic and environmental factors underlie the development and maintenance of chronic pain in children. Critical questions need to be addressed before efforts at prevention and intervention can have maximum impact. The four aims address four key questions for the field of pain research: 1) genetic and environmental etiology of pain, 2) transmission of pain across generations, 3) the role of environmental risk and protective factors in pain, and in moderating the heritability of pain, and 4) the growth in pain, including the bidirectional relations between pain and general dysregulation across development. Chronic pain is often comorbid with mood disorders, and we examine the extent to which pain and mood, behavioral and physiological dysregulation share a common etiology. To accomplish our aims, we propose to conduct longitudinal follow ups (9, 10 and 11 years of age) of a birth-records-based community sample of 350 pairs of ethnically diverse twin children. Early risk and resilient aspects of the environment have already been well-characterized, including obstetrical complications and neonatal morbidity coded from medical records, and early parenting. The multi-method approach includes objective assessments of pain frequency, intensity, duration, and disability in twin children and their mothers and fathers. Combining these design features exponentially increases the scientific contribution by elucidating processes that will support preventive intervention efforts.