IP Landscape Search for Applications of Fluorescent Nanodiamonds

摘要 这项合作伙伴关系提案的广泛目标是进行一项知识产权前景研究 在生物医学和医药市场上使用荧光钻石。内华达州-中心 纳米钻石显示出明亮的、高度稳定的荧光，这种荧光延伸到近红外 光谱区域。它们是生物相容的，永不褪色，可光漂白或眨眼，并显示荧光 这比常用的有机染料要亮得多。这些特征使荧光 纳米钻石非常适合药物输送和生物医学成像应用，如细胞 用于超分辨率显微镜的标记、细胞跟踪和基准标记。荧光 钻石和纳米钻石在其他领域还有其他基本上未被开发的应用 现场传感器、自旋电子学等市场，以及在药品防伪、医疗 仪器、植入物和诊断试剂盒。而荧光纳米钻石的机会 虽然看起来有利可图，但直到现在还没有商业来源的荧光纳米钻石 Columbus NanWorks获得了生产荧光纳米钻石的第一阶段SBIR合同 在商业规模上。我们目前处于第二阶段SBIR合同的第6个月，以继续 这项工作以及开发额外的钻石颜色中心。现在需要的一个主要领域 我们的注意力是了解荧光钻石的知识产权前景。我们要求 来自商业化准备计划的资金，以谨慎地进行智力 物业搜索和景观分析侧重于成分、生产方法和 荧光钻石和纳米钻石的应用。作为荧光钻石和 纳米钻石是新的，我们相信围绕它们的知识产权将相当有限，并且一个 IP景观搜索将加强我们在这一市场的地位。这项研究将使我们能够 发展和保护我们的产品，最大限度地发挥我们的商业竞争潜力。更深一层的 了解荧光纳米钻石领域的知识产权将使我们能够 调动我们的发展努力以实现最大利益，发展富有成效的伙伴关系和 吸引投资者，开发技术解决方案和业务战略，以避免自由 执业/侵权风险。

ABSTRACT The broad objective of this CRP proposal is to conduct an intellectual property landscape study for the use of fluorescent diamonds in biomedical and pharmaceutical markets. NV-center nanodiamonds exhibit bright, highly stable fluorescence which extends into the near infrared spectral region. They are biocompatible, never fade, photobleach or blink and show fluorescence that is much brighter than commonly used organic dyes. These features make fluorescent nanodiamonds ideally suited for drug delivery and biomedical imaging applications, such as cell labeling, cell tracking, and fiducial marking for super resolution microscopy. Fluorescent diamonds and nanodiamonds have additional and essentially untapped applications in other markets such as field sensors, spintronics, and in anti-counterfeiting of pharmaceuticals, medical instruments, implants and diagnostic kits. While the opportunity for fluorescent nanodiamonds appears lucrative, there were no commercial sources of fluorescent nanodiamonds until Columbus NanoWorks received a Phase I SBIR contract to produce fluorescent nanodiamonds on a commercial scale. We are currently in month 6 of our Phase II SBIR contract to continue this work as well as develop additional diamond color centers. A major area that now requires our attention is understanding the IP landscape for fluorescent diamonds. We are requesting funding from the Commercialization Readiness Program to carefully conduct an intellectual property search and landscape analysis focused on compositions, production methods and applications of use for fluorescent diamonds and nanodiamonds. As fluorescent diamonds and nanodiamonds are new, we believe that the IP surrounding them will be fairly limited and that an IP landscape search will strengthen our position in this market. This study will enable us to advance and protect our products and maximize our commercial competitive potential. A deeper understanding of the intellectual property in the fluorescent nanodiamond space will allow us to maneuver our development efforts for the greatest benefit, develop productive partnerships and attract investors, and develop technical solutions and business strategies to avoid freedom to practice/infringement risks.