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Development Of A Vaccine For Leishmania Major Infection

Development Of A Vaccine For Leishmania Major Infection
开发利什曼原虫重大感染疫苗
批准号：
9161749
负责人：
ROBERT A SEDER
金额：
$19.5万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/9161749
关键词：
Activities of Daily LivingAdjuvantAntibodiesAntibody FormationAntigensCD4 Positive T LymphocytesCD8B1 geneCellular ImmunityCellular ImmunologyClinicalDevelopmentDiseaseDrug FormulationsEnhancing AntibodiesEquilibriumFlow CytometryGenerationsGoalsHIVImmuneImmune responseImmunityImmunizationInfectionInterferonsLeadLeishmaniaLeishmania majorLigandsMaintenanceMalariaMediatingModelingMorbidity - disease rateMusMycobacterium tuberculosisPatternPlayPolymersProductionProteinsRoleT cell responseT-LymphocyteTh1 CellsTh2 CellsToll-like receptorsToxic effectVaccinationVaccinesbasecost effectivecytokinekillingslymph nodesmortalitynonhuman primatenovelpathogenresponsevaccine development

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中文摘要
翻译
利什曼原虫感染在世界范围内导致严重的发病率和死亡率。感染宿主的利什曼原虫种类和宿主产生的免疫反应决定了所见临床疾病的谱系。特别是，T细胞产生细胞因子的模式对保护至关重要。目前还没有一种易于管理、有效且成本效益高的利什曼病疫苗。在过去的一年里，我们开发了使用聚合物和免疫增强来交付疫苗的新方法，这些方法共同导致了更强大的免疫反应，但限制了任何毒性。
英文摘要
Infection with Leishmania causes significant morbidity and mortality worldwide. The type of Leishmania species infecting the host and the immune response generated by the host determines the spectrum of clinical disease that is seen. In particular, the pattern of cytokine production from T cells is critical for protection. At present there is no vaccine for Leishmania that is easy to administer, efficacious, and cost effective. Over the past year we developed new way to deliver vaccines using polymers and immune enhances that together lead to more robust immune responses but limits any toxicity.
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VACCINE DEVELOPMENT FOR TUBERCULOSIS
  • 批准号：
    7958684
  • 项目类别：
  • 资助金额：
    $5.57万
  • 财政年份：
    2009
  • 负责人：
    ROBERT A SEDER
  • 依托单位：
    TULANE UNIVERSITY OF LOUISIANA
DNA VACCINATION FOR PREVENTION OF VIRAL, PARASITIC AND MYCOBACTERIAL INFECTION
Development Of A Vaccine For Leishmania Major Infection
Development Of A Vaccine For Leishmania Major Infection
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