Peptide Therapeutics for the Treatment of Autoimmune Diseases: Stability, Delivery and Disposition

自身免疫性疾病影响着全球约1.2亿人。该项目将推动一种在不影响保护性反应的情况下抑制致病自身抗原特异性免疫反应的多肽的开发。将对这种多肽的不同给药途径以及延长其体内寿命的缓释制剂进行评估。结果将是一种对患者友好的形式的这种治疗线索，可以被推进到临床前评估。

Autoimmune diseases affect around 120 million people worldwide. This project will progress the development of a peptide that suppresses disease-causing autoantigen-specific immune responses without affecting protective responses. Different routes of delivery for this peptide will be evaluated, as well as slow-release formulations that will extend its in vivo lifetime. The outcome will be a patient-friendly form of this therapeutic lead that can be taken forward to preclinical evaluation.