Pesonalised risk prediction for severe treatment-related gastrointestinal toxicity in paediatric cancer patients using pre-treatment gut microbiome analysis

肠道是数万亿有益和有害细菌的家园，对人类健康至关重要。每个人的肠道都有不同的细菌平衡，这决定了他们的免疫系统和对疾病的易感性。我将研究如何利用患有血癌的儿童的独特肠道细菌来预测哪些儿童在化疗后会出现严重的肠道副作用（腹泻）。这将确定高危儿童，使个性化治疗成为可能，并提高生存率。

The gut is home to trillions of good and bad bacteria, critical to human health. Each person has a different balance of bacteria, unique to their gut, which shapes their immune system and susceptibility to disease. I will investigate how the unique gut bacteria, in children with blood cancer, can be used to predict which children will develop severe gut side effects (diarrhoea) from their chemotherapy. This will identify high-risk children, enable personalised treatment and improve survival.