Processes underlying establishment and maintenance of the latent HIV resevoir and potential impact of integrase inhibitors

目前对艾滋病毒感染者的治疗能够控制病毒的生长，但不能根除病毒感染。这是由于含有潜伏状态的HIV DNA的CD4+ T淋巴细胞池，一旦治疗中断就准备重新激活。该项目旨在更好地了解这种潜伏感染的CD4+ T淋巴细胞库是如何建立和维持的，特别是它如何与白细胞介素7的基本T细胞存活信号相关联。

Therapy for HIV-infected individuals is currently able to control the growth of the virus, but cannot eradicate the viral infection. This is due to a pool of CD4+ T lymphocytes which contain HIV DNA in a latent state, ready to reactivate as soon as therapy is interrupted. This project aims to better understand how this pool of latently infected CD4+ T lymphocytes is established and maintained, particularly how it is linked to the essential T cell survival signal from interleukin 7.