Proteomics of arthritis: Exploring mechanisms of cartilage degradation and biomarker identification

关节炎是一个重大的临床和社会经济问题。关节炎涉及关节软骨的破坏。然而，软骨破坏的发生和发展的机制仍不清楚。我们的研究将使用新的蛋白质组学方法来识别关节炎小鼠模型中蛋白质合成和降解的变化。这将为疾病机制以及诊断生物标记物和治疗方法的发展提供关键信息。

Arthritis is a major clinical and socio-economic problem. Arthritis involves the destruction of cartilage in joints. However, the mechanisms of initiation and progression of cartilage destruction remain poorly understood. Our studies will use new proteomic approaches to identify the changes in protein synthesis and degradation in mouse models of arthritis. This will provide critical information on disease mechanisms and for the development of diagnostic biomarkers and therapeutic approaches