Alternative pneumococcal vaccination schedules for infants in Fiji and pneumococcal epidemiology

本研究的目的是为资源贫乏的国家找到一种安全和流行病学上适当的肺炎球菌疫苗接种策略。斐济正在进行一项单盲、开放标签随机II期研究，记录了各种肺炎球菌疫苗接种方案的安全性、免疫原性和对肺炎球菌携带的影响，这些方案在婴儿期联合接种1、2或3剂7价肺炎球菌结合疫苗（PCV），然后再接种单剂23价肺炎球菌多糖疫苗。

The aim of this study is to find a safe and epidemiologically appropriate pneumococcal vaccination strategy for resource poor countries. A single, blind open-label randomized Phase II study is underway in Fiji documenting the safety, immunogenicity and impact on pneumococcal carriage of various pneumococcal vaccination regimens combining 1, 2, or 3 doses of 7-valent pneumococcal conjugate vaccine (PCV) in infancy followed by a single booster dose of 23-valent pneumococcal polysaccharide vaccine.