An abnormal inflammatory response following wrist fracture causes the development of complex regional pain syndrome (CRPS).

该项目将有助于了解是什么原因导致一些人发展为复杂区域疼痛综合征（CRPS）。大约5%的人在骨折后会发生CRPS，但也可能发生在轻微损伤的情况下。患者会经历逐渐恶化的疼痛、皮肤变色、生活质量差，通常还会出现严重的抑郁症。我们将调查CRPS最可能的原因，这被认为是损伤后的异常炎症反应。

This project will contribute essential knowledge about what causes some people to develop Complex Regional Pain Syndrome (CRPS). CRPS affects approximately 5% of people following a fracture but can also occur with minimal injury. Sufferers experience gradually worsening levels of pain, skin discolouration, poor quality of life, and often severe depression. We will investigate the most likely cause of CRPS, which is thought to be an abnormal inflammatory reaction following injury.