Rapid, point of care diagnostic tests to differentiate HA subtypes in patients samples

目前有许多快速的即时检测方法可用于检测人类和禽流感类型，但它们的灵敏度差别很大。特别是，这些检测是基于当前的H5（禽流感）流感毒株，可能无法检测到变异毒株或大流行毒株，阴性结果可能给人一种错误的印象，即患者没有感染H5流感。我们将开发基于病毒高度保守部分的快速即时检测方法，以便能够以相同的灵敏度检测到所有H5毒株（当前和未来），以及目前在人体内发现的H1和H3毒株，以提供明确的诊断。这些检测在识别和区分大流行性流感病例方面很有价值，可以更好地利用公共卫生资源，特别是在标准（H1和H3）流感感染持续的背景下。

A number of rapid, point-of-care tests are available for the detection of human and avian influenza types, but they vary greatly in sensitivity. In particular, these tests are based on current strains of H5 (avian) influenza, and may be unable to detect variant or pandemic strains, and negative results can give the false impression that patients do not have H5 influenza. We will develop rapid, point-of-care tests based on highly conserved parts of the virus, so that all H5 strains (current and future) can be detected with equal sensitivity, along with the H1 and H3 strains that are currently found in man to provide a definitive diagnosis. These tests will be valuable in the identification and differentiation of pandemic influenza cases, allowing better use of public health resources, especially against a background of continuing standard (H1 and H3) influenza infections.