Rates of psychosis onset in a high risk population

对有精神分裂症风险的人的早期研究发现，大约35%的人在1年内发展为精神病。然而，最近风险已降至10%。他们可能仍然会成为精神病，但需要更长的时间才能做到这一点，或者他们可能根本不会发展精神病。我们需要研究这一点，以便那些没有“危险”的人不会受到不必要的治疗。我们将对“高危”人群进行随访，并确定他们6年的结局。我们将做扫描，看看是否有任何与精神病有关的大脑变化。

Older studies of people at risk of schizophrenia found that about 35% of them developed psychosis within 1 year. However the risk has decreased lately to as low as 10%. They may still become psychotic but take longer to do so, or they may not develop psychosis at all. We need to study this so that those not “at risk” are not needlessly treated. We will follow up “at risk” people and determine their 6 year outcome. We will do scans to see if there are any brain changes associated with psychosis.