Rationale for non-invasive treatment of Retinopathy of Prematurity: Dark Rearing as a means of mimicking physiological vascularisation

我们的目标是开发一种新的、非侵入性的、具有成本效益的治疗早产儿视网膜病变的方法，这是全球儿童失明的主要原因。我们打算验证我们的假设，即在完全黑暗和高氧的条件下抚养新生儿，将密切模仿诱导正常视网膜血管发育的条件，从而防止疾病的初始事件。最终，该项目打算为翻译成人类状况奠定基础。

We aim to develop a new, non-invasive and cost-effective treatment for the disease Retinopathy of Prematurity, the leading cause of childhood blindness across the globe. We intend to test our hypothesis that raising neonates in conditions of total darkness and high oxygen will closely mimic conditions for inducing normal retinal vascular development, and thus prevent the initiating event of the disease. Ultimately, the project intends to lay the groundwork for a translation to the human condition.