REACH: Randomised trial of EArly Rehabilitation in Congenital Hemiplegia

患有不对称脑损伤的婴儿患先天性偏瘫的风险很高。这项研究在150名3-6个月大的婴儿中比较了改良的CIMT和等剂量的双手训练。这两种疗法都将由经验丰富的临床医生提供支持。结果包括在12个月和24个月时使用受损的手进行双手任务，认知和运动发展，并在24个月时测量神经结构和功能连接。早期干预会减弱

Infants with asymmetric brain lesions are at high risk of congenital hemiplegia. This study compares modified CIMT to an equal dose of bimanual training in 150 infants recruited at 3-6 months. Both therapies will be parent-delivered supported by experienced clinicians. Outcomes include use of the impaired hand in bimanual tasks, cognitive and motor development at 12 and 24 months c.a. with measures of neural structure and functional connectivity at 24 months. Early interventions that attenuate