Redefining antibiotic resistance plasmid transfer in Staphylococcus aureus

耐多药金黄色葡萄球菌是一个主要的健康问题。由于细菌有效地获得/共享耐药基因，耐药性迅速发展。我们的发现表明，DNA转移机制比以前预期的更加多样化和广泛，这对许多致病生物具有广泛的影响。该项目旨在确定每种机制的流行程度和关键特征，以便设计治疗方法来破坏耐药性的演变和传播。

Multidrug-resistant Golden Staph bacteria are a major health problem. Resistance develops rapidly because bacteria efficiently acquire/share resistance genes. Our discoveries suggest DNA transfer mechanisms are far more diverse and widespread than previously expected and this has wide-reaching implications for numerous pathogenic organisms. This project aims to define the prevalence and key features of each mechanism so treatments can be devised to disrupt the evolution and spread of resistance.